Diminished effect of etidronate in vitamin D deficient osteopenic postmenopausal women
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Objective: The effects of vitamin D deficiency in osteopenic postmenopausal women treated with intermittent cyclical etidronate have been studied. Bone mass and biochemical parameters as bone markers were measured before and after one year of therapy with intermittent cyclical etidronate.
In 30 patients without vitamin D deficiency, bone mass in the lumbal spine and femoral neck was significantly increased compared to 28 vitamin D deficient patients. After cyclical intermittent etidronate therapy, serum osteocalcin and PTH were significantly increased in the vitamin D deficient patients, whereas in non-vitamin D deficient patients they did not change.
It is worthwhile measuring serum vitamin D before starting etidronate therapy and, in case of deficiency, to give vitamin D.
- Diminished effect of etidronate in vitamin D deficient osteopenic postmenopausal women
European Journal of Clinical Pharmacology
Volume 51, Issue 2 , pp 145-147
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- Key words Etidronate
- Vitamin D deficiency; postmenopausal women
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- Author Affiliations
- A1. Medisch Onderzoekcentrum Good Clinical Practice, Groot Hertoginnelaan 34, NL-2517 EH Den Haag, The Netherlands, NL
- A2. Praktijk voor laboratoriumdiagnostiek, Burg. Van de Minnelaan 3, NL-3211 AE Geervliet, The Netherlands, NL
- A3. Medisch Onderzoekcentrum Good Clinical Practice, Walenburgerweg 33, NL-3039 AC Roterdam, The Netherlands, NL