Longitudinal prevalence of potentially inappropriate medicines and potential prescribing omissions in a cohort of community-dwelling older people
This study aims to compare the prevalence of potentially inappropriate medicines (PIMs) and potential prescribing omissions (PPOs) using several screening tools in an Irish community-dwelling older cohort, to assess if the prevalence changes over time and to determine factors associated with any change.
This is a prospective cohort study of participants aged ≥65 years in The Irish Longitudinal Study on Ageing (TILDA) with linked pharmacy claims data (n = 2051). PIM and PPO prevalence was measured in the year preceding participants’ TILDA baseline interviews and in the year preceding their follow-up interviews using the Screening Tool for Older Persons’ Prescriptions (STOPP), Beers criteria (2012), Assessing Care of Vulnerable Elders (ACOVE) indicators and the Screening Tool to Alert doctors to Right Treatment (START). Generalised estimating equations were used to determine factors associated with change in prevalence over time.
Depending on the screening tool used, between 19.8 % (ACOVE indicators) and 52.7 % (STOPP) of participants received a PIM at baseline, and PPO prevalence ranged from 38.2 % (START) to 44.8 % (ACOVE indicators), while 36.7 % of participants had both a PIM and PPO. Common criteria were aspirin for primary prevention (19.6 %) and omission of calcium/vitamin D in osteoporosis (14.7 %). Prevalence of PIMs and PPOs increased at follow-up (PIMs range 22–56.1 %, PPOs range 40.5–49.3 %), and this was associated with patient age, female sex, and numbers of medicines and chronic conditions.
Sub-optimal prescribing is common in older patients. Ongoing prescribing review to optimise care is important, particularly as patients get older, receive more medicines or develop more illnesses.
KeywordsSTOPP START Beers criteria ACOVE indicators Cohort Potentially inappropriate prescribing
Medicines are the most common healthcare intervention worldwide, and despite providing many benefits, they also carry potential risks which can lead to patient harm . Physiological changes in ageing which alter drug pharmacodynamics and pharmacokinetics can predispose older people to adverse drug events . Additionally, older people are more likely to be taking multiple medicines and have multiple medical conditions, increasing the likelihood of drug-drug or drug-disease interactions [2, 3, 4].
Due to concerns regarding appropriate medication use in this age group, a number of screening tools/criteria have been devised to define what constitutes potentially inappropriate prescribing (PIP) in the elderly. PIP can be classified as either (i) potentially inappropriate medicines (PIMs), the use of a medicine where no clear clinical indication exists or the use of an indicated medicine in circumstances where the risks outweigh the benefits, or (ii) potential prescribing omissions (PPOs), not prescribing a beneficial medicine for which there is a clear clinical indication .
Although PIP can be determined implicitly on the basis of clinician’s judgement, the majority of research has determined it explicitly using published criteria/screening tools, a large number of which have been developed . The earliest such tool was Beers criteria, first published in 1991 as a list of drugs to be avoided in older nursing home residents . It contained many medicines not commonly prescribed outside of the USA, and updates to the Beers criteria include drugs which are more widely used internationally and also drugs to avoid with certain conditions . Although earlier iterations of the Beers criteria have been used extensively in the literature, the 2012 criteria have yet to be widely applied . The Screening Tool for Older Person’s Prescriptions (STOPP) and Screening Tool to Alert doctors to Right Treatment (START) were developed as screening tools for PIMs and PPOs, respectively, suitable for use in European countries and have been applied and validated in the literature [9, 10, 11, 12]. Outside of specific PIP screening tools, the Assessing Care of Vulnerable Elders (ACOVE) indicators were developed by the Research and Development (RAND) Corporation to assess the overall quality of care of older people . Several ACOVE indicators relate to PIMs and PPOs, and these have been assessed for use as a PIP screening tool and have good inter-rater reliability [14, 15].
Much published literature on this topic has only focussed on PIMs with few studies utilising PPO screening tools. Of those studies that considered both PIMs and PPOs, none have reported how these two forms of PIP overlap [16, 17, 18, 19, 20, 21]. Additionally, little is known about how the prevalence of PIMs and PPOs changes over time in older populations and determinants of change. This study aims to (i) compare the prevalence of potentially inappropriate prescribing (both PIMs and PPOs) in a cohort of community-dwelling people aged 65 years and older in Ireland according to a number of screening tools and (ii) assess if the prevalence of potentially inappropriate prescribing in this cohort changes over time and to determine the factors associated with any change.
The population for this prospective cohort study comprised a subset of participants in The Irish Longitudinal Study on Ageing (TILDA) for whom medication dispensing history was available. TILDA is a nationally representative cohort study of more than 8000 community-dwelling people aged 50 years or over charting their health, social, and economic circumstances (see Supplementary file 1 for details of collected information). TILDA participants were deemed eligible for this study if they were aged 65 years or older at baseline and supplied a valid General Medical Services (GMS) identifier to allow linkage of their medication dispensing history from the Health Service Executive Primary Care Reimbursement Service (HSE-PCRS) pharmacy claims database. The HSE-PCRS GMS scheme provides free health services to eligible persons in Ireland, including a wide range of prescribed medicines, although a monthly co-payment per prescription item has applied since October 2010. Eligibility for the GMS scheme is based on means testing, although all people aged over 70 were eligible until December 2008 when a higher income threshold was introduced for this age group compared to the general population.
TILDA participant recruitment and wave 1 baseline data collection were carried out between 2009 and 2011 when participants were interviewed face to face, completed a questionnaire and underwent a health assessment. TILDA follow-up waves are scheduled every 2 years, the first of which was carried out from February 2011 to March 2012. Medication data were extracted from the HSE-PCRS pharmacy claims database on the basis of GMS identifier for each participant in the present study for the 15 months preceding the date of their TILDA baseline and follow-up interviews. The HSE-PCRS database contains a GMS identifier, sex and date of birth, drug information (World Health Organisation Anatomical Therapeutic Chemical (ATC) code, strength, defined daily dosage (DDD)), quantity dispensed and date of dispensing. Linkage of participants’ TILDA and HSE-PCRS dispensing data was carried out using methods published previously . All data were anonymised after linkage was performed. Ethical approval for TILDA was provided by the Faculty of Health Sciences Ethics Committee at Trinity College Dublin.
Potentially inappropriate prescribing criteria
The prevalence of PIP was measured during two time intervals: in the 12 months preceding each participant’s baseline TILDA interview and in the 12 months preceding their follow-up interview. A longer period of time was analysed for criteria dependent on duration of medication use of greater than 1 month to allow for 12 months of potential exposure. Dispensing data from the HSE-PCRS database and information from TILDA on diagnoses, medications not included in the HSE-PCRS database (self-reported) and other characteristics were used to assess if participants had received a PIM or had a PPO. Participants were classified as having a PIM if they were prescribed the potentially inappropriate medicine at any time during the study periods, while having a PPO was classified as not receiving the indicated medicine at any time during the study periods.
A subset of criteria from STOPP, Beers criteria (2012) and the third iteration of the ACOVE indicators were applied to dispensing data and information from TILDA to measure PIMs. Forty-five of 65 (69 %) STOPP criteria, 42 of 52 (81 %) Beers criteria and 17 of 22 (77 %) ACOVE indicators relating to inappropriate medicines were used. To measure PPOs, a subset of criteria from START and the ACOVE indicators were used. Fifteen of 22 (68 %) START criteria were applicable, while 21 of 65 (34 %) ACOVE indicators relating to prescribing indicated that medicines could be applied. All criteria for which the necessary participant information was available in the HSE-PCRS pharmacy claim that database and TILDA were applied.
Prevalence estimates were calculated for each set of PIM and PPO criteria as well as for each individual criterion. Additionally, the prevalence of each criterion (where applicable) as a proportion of the number of participants with the condition/disease or prescribed the drug of interest was determined, for example, of those prescribed a benzodiazepine during the study period, the proportion who were prescribed it for >4 weeks. McNemar’s test for paired groups comparison was used to test whether the prevalence of criteria changed significantly between the two time periods. Generalised estimating equations (GEE) with exchangeable correlations were used to investigate determinants of the change in prevalence of PIMs and PPOs . Unadjusted analysis estimating change in overall PIM and PPO prevalence from baseline to follow-up was followed by multivariable GEE analysis which adjusted for sex, age, numbers of regular medicines and diagnosed chronic conditions (reported at TILDA interview) at baseline and follow-up in the models. Level of educational attainment as an indicator of socio-economic status was assessed for inclusion in the models. Analyses were performed using SAS 9.2 (SAS Institute Inc., Cary, NC, USA) and Stata version 12 (Stata Corporation, College Station, TX, USA).
Prevalence of potentially inappropriate medicine use and potential prescribing omissions
Number of participants with PIMs and PPOs at baseline and 2-year follow-up
% (95 % CI)
% (95 % CI)
52.7 (50.5, 54.8)
56.1 (54.0, 58.3)
29.8 (27.8, 31.8)
29.4 (27.4, 31.3)
13.2 (11.7, 14.6)
15.0 (13.4, 16.5)
9.8 (8.5, 11.0)
11.8 (10.4, 13.2)
30.5 (28.5, 32.5)
33.1 (31.0, 35.1)
15.8 (14.3, 17.4)
17.0 (15.4, 18.6)
9.4 (8.1, 10.6)
9.9 (8.6, 11.2)
5.3 (4.3, 6.2)
6.1 (5.1, 7.2)
19.8 (18.1, 21.6)
22.0 (20.2, 23.8)
16.4 (14.8, 18.0)
18.1 (16.5, 19.8)
3.0 (2.3, 3.8)
3.1 (2.3, 3.8)
0.4 (0.2, 0.7)
0.8 (0.4, 1.2)
Any above PIMa
61.4 (59.3, 63.5)
64.8 (62.8, 66.9)
38.2 (36.1, 40.3)
40.5 (38.4, 42.6)
26.9 (24.9, 28.8)
28.6 (26.6, 30.5)
8.3 (7.1, 9.5)
8.3 (7.1, 9.5)
3.0 (2.2, 3.7)
3.6 (2.8, 4.4)
44.8 (42.6, 46.9)
49.3 (47.1, 51.5)
22.7 (20.9, 24.5)
24.1 (22.2, 25.9)
13.6 (12.1, 15.1)
16.1 (14.5, 17.7)
8.5 (7.3, 9.7)
9.1 (7.8, 10.3)
Any above PPOa
53.3 (51.2, 55.5)
56.6 (54.5, 58.8)
Prevalence of individual PIM criteria (prevalence ≥2 %) at baseline and 2-year follow-up
% of sample
% of indicationa
% of sample
% of indicationa
Change in prevalence (95 % CI)
Loop diuretic for dependent ankle oedema only
0.8 (−0.6, 2.2)
Aspirin with history of PUD without H2 receptor antagonist or PPI
−0.1 (−0.9, 0.7)
Aspirin with no history of coronary, cerebral or peripheral arterial symptoms or occlusive arterial event
−1.2 (−3.9, 1.4)
Central nervous system
TCAs with an opiate or calcium channel blocker
1.1 (0.1, 2.1)**
Long-term (>1 month), long-acting benzodiazepines
−0.8 (−1.9, 0.4)*
PPI at full therapeutic dosage for >8 weeks
4.7 (2.0, 7.4)***
NSAID with history of PUD, unless with concurrent H2 receptor antagonist, PPI or misoprostol
0.2 (−0.6, 1.0)
NSAID with moderate-severe hypertension >160/100 mmHgb
1.0 (−0.9, 2.9)
Long-term use of NSAID (>3 months)
0.4 (−1.0, 1.8)
Long-term corticosteroids (>3 months) as monotherapy for rheumatoid arthrtitis/osteorarthritis
0.5 (−0.4, 1.4)
Drugs that adversely affect fallers
Benzodiazepines in those prone to falls
−0.4 (−1.4, 0.6)
Neuroleptic drugs in those prone to falls
0.7 (−0.1, 1.6)
Regular opiates for >2 weeks without concurrent use of laxatives
−0.3 (−1.7, 1.1)
Duplicate drug classes
Any regular duplicate drug class prescription
0.7 (−0.3, 1.8)
Beers criteria (2012)
0.5 (−0.3, 1.4)
Central nervous system
1.1 (−0.3, 2.5)*
Benzodiazepines, short, intermediate and long acting
Non-benzodiazepine (Z-drug) hypnotics, avoid chronic use >90 days
0.4 (−0.6, 1.4)
1.0 (0.2, 1.7)*
Non-COX-selective NSAIDs, avoid chronic use
−0.6 (−1.8, 0.7)
Avoid with history of falls/fractures (fracture and fall or > 1 fall or >1 fracture) (total)
2.1 (0.5, 3.8)***
1.3 (0.5, 2.0)***
0.6 (−0.5, 1.7)
0.9 (−0.1, 1.8)
0.2 (−0.6, 1.1)
Falls and mobility problems
If ≥2 falls (or 1 fall with injury) in previous year discontinue benzodiazepine
0.0 (−0.8, 0.9)
If a vulnerable elder (VE) has HTN discontinue NSAID or COX-2 inhibitorb
0.0 (−1.2, 1.3)
Discontinue benzodiazepine if taking for >1 month
−0.8 (−1.9, 0.4)*
Avoid medication with strong anticholinergic effects
2.1 (−0.1, 4.3)**
In iron-deficiency anaemia, prescribe no more than one low-dose oral iron tablet daily
0.8 (0.0, 1.6)
Prevalence of individual PPO criteria (prevalence ≥2 %) at baseline and 2-year follow-up
% of sample
% of indicationa
% of sample
% of indicationa
Change in prevalence (95 % CI)
Warfarin (or another oral anticoagulant) in the presence of chronic atrial fibrillation
1.8 (0.1, 3.4)***
Aspirin/clopidogrel with a history of atherosclerotic coronary, cerebral or peripheral vascular disease
0.1 (−0.7, 1.0)
Antihypertensive therapy where systolic blood pressure >160 mmHgb
−2.0 (−3.4, −0.6)***
Statin therapy with a history of coronary, cerebral or peripheral vascular disease
0.7 (−0.3, 1.8)*
ACE inhibitor following acute MI
−0.1 (−1.0, 0.8)
β blocker with chronic stable angina
−0.1 (−1.2, 0.9)
Regular inhaled β2 agonist or anticholinergic agent for mild to moderate asthma or COPD
0.7 (−0.6, 2.0)
Bisphosphonates if taking oral corticosteroids for >3 months
0.4 (−0.5, 1.4)
Calcium and vitamin D supplement with osteoporosis
1.4 (−0.9, 3.6)*
Antiplatelet therapy in diabetes mellitus if ≥1 major CV risk factor (hypertension, hypercholesterolaemia, smoking history)
0.4 (−0.5, 1.4)
Statin therapy in diabetes mellitus if ≥1 major CV risk factor
1.4 (−0.9, 3.6)
If a VE has COPD, prescribe a rapid-acting bronchodilator
1.1 (0.3, 2.0)***
If a VE with COPD has 2+ exacerbations requiring antibiotics/oral corticosteroids in the previous year, then (in addition to a long-acting bronchodilator) prescribe inhaled steroids (if not taking oral steroids)
1.0 (0.4, 1.6)
If a VE with diabetes mellitus not on anticoagulant or antiplatelet, then daily aspirin should be prescribed
0.2 (−0.7, 1.1)
If a VE with HTN has IHD, prescribe a β blockerc
0.0 (−0.9, 1.0)
If a VE with HTN has a history of HF, IHD, chronic kidney disease or CV accident, prescribe an ACE inhibitor/ARBc
0.1 (−0.9, 1.1)
Ischaemic heart disease
If a VE has had an MI, prescribe a β blocker
−0.1 (−1.0, 0.8)
If a VE has IHD, prescribe an ACE inhibitor/ARB
0.0 (−1.0, 1.1)
If a VE with a risk factor for GI bleeding (aged ≥75, PUD, warfarin use, chronic glucocorticoid use) is prescribed a non-selective NSAID, treat concomitantly with misoprostol/a PPI
−1.2 (−3.0, 0.5)
If a VE without osteoporosis is taking ≥7.5 mg/day of prednisone (or equivalent) for ≥1 month, prescribe calcium and vitamin D
0.0 (−0.8, 0.8)
If a VE has osteoporosis, prescribe calcium and vitamin D supplements
1.4 (−0.9, 3.6)
If a female VE has osteoporosis, treat with bisphosphonate, raloxifene, calcitonin, HRT or teriparatide
3.1 (1.2, 4.9)***
If a male VE has osteoporosis, treat with bisphosphonate, calcitonin, parathyroid hormone or testosterone
1.0 (−0.4, 2.5)***
If a VE with persistent pain is treated with opioids, prescribe a stool softener/laxative
2.0 (0.0, 3.9)*
If a VE has had a TIA or stroke, prescribe antiplatelet/anticoagulant therapy
0.8 (−0.4, 1.9)**
Change in prevalence over time
The prevalence of PIMs and PPOs increased significantly (p < 0.05) between the baseline and follow-up study periods for each screening tool (Table 1). At follow-up, 64.8 % of participants received a PIM, and 56.6 % received a PPO defined by any of the screening tools, while the proportion of the sample with both a PIM and PPO increased to 41.1 % (843 participants).
Population-averaged GEE models for change in sample prevalence of PIMs and PPOs
Adjusted odds ratio (95 % CI) (n = 2046a)
Follow-up (vs baseline)
1.00 (0.95, 1.06)
1.03 (1.02, 1.04)*
1.03 (1.02, 1.04)*
Female (vs male)
1.27 (1.07, 1.5)*
0.86 (0.72, 1.01)
Number of medicines
1.20 (1.17, 1.24)*
1.04 (1.01, 1.07)*
Number of chronic conditions
1.05 (0.99, 1.11)
1.47 (1.39, 1.56)*
The most common PIM and PPO criteria (prevalence >2 %) during the follow-up period are presented in Tables 2 and 3, respectively. A number of individual criteria showed highly significant (p < 0.0001) increases in prevalence between baseline and follow-up, including prescription of PPIs at full therapeutic dosage for >8 weeks (STOPP, 17.2 to 21.9 %). Only prescription of long-term (>1 month) long-acting benzodiazepines (STOPP/ACOVE, 3.9 to 3.1 %) and omission of antihypertensives in participants with elevated blood pressure (START, 5.5 to 3.5 %) significantly decreased in prevalence.
Statement of principal findings
This study showed in a cohort of 2051 community-dwelling people aged 65 and over, more than 61 % received a PIM in a 1-year period defined by a subset of STOPP criteria, Beers criteria and ACOVE indicators, while 53 % had a PPO defined by a subset of START criteria and ACOVE indicators. Aspirin for primary prevention, prolonged use of full therapeutic dosage PPIs and strong anticholinergic drugs were the most common PIMs, while common omissions were calcium and vitamin D in osteoporosis, laxatives for patients on opioids and gastro-protection with an NSAID. The increase in PIM and PPO prevalence between baseline and follow-up is associated with patient characteristics (age, female sex, numbers of prescribed medicines and chronic conditions) rather than being a function of time.
Results in the context of current literature
It is not surprising that the prevalence varies depending on the screening tool used as each includes different types of prescribing in what is classified as potentially inappropriate. Also, the Beers criteria and ACOVE indicators were first developed for use in the USA, whereas STOPP and START are more widely applicable. A number of studies have estimated the prevalence of PIP using multiple screening tools. Prevalence estimates have been highly variable as research has been carried out across settings (hospitals, residential care, community), in a number of countries and using data ranging from full clinical records to administrative data meaning that only a subset of PIP criteria have been applied .
A systematic review of studies applying the STOPP and/or START criteria found prevalence ranging from 21 to 79 % for PIMs and 22 to 74 % for PPOs . PIM prevalence according to the Beers criteria varied from 3 to 40 % in studies included in a review of the 1991 Beers criteria, and up to 53.4 % using more recent iterations of Beers criteria [24, 25]. The ACOVE indicators have not been applied extensively, with two studies reporting the prevalence of ACOVE PPOs giving estimates of 58 and 58.5 % [14, 26]. A previous study of TILDA participants using STOPP/START reported lower PIM and PPO prevalence at baseline interview than the current study (14.6 and 30 %) ; however, fewer criteria were applied and prevalence was measured at one time point rather than over a period of 12 months.
A number of studies have assessed the prevalence of both PIMs and PPOs; however, the present study appears to be the first to report on the proportion of study participants with concurrent PIMs and PPOs [16, 17, 18, 19, 20, 21]. An association has been demonstrated between polypharmacy (using ≥ five medications concomitantly) and underprescribing , so the high rate of concurrent PIMs and PPOs is not unexpected.
Few epidemiological studies have reported the longitudinal prevalence of PIP, and findings have shown a trend of PIP decreasing over time [28, 29]. A cohort study which, like the present study, controlled for numbers of prescribed medicines and co-morbidities found that sub-optimal prescribing remained unchanged or decreased over a 4-year follow-up period after adjusting for these factors .
Clinical and policy implications
Potentially inappropriate prescribing in older people is a common issue and warrants attention to improve the quality of care provided to this age group. However, this complex problem may not be accurately captured using administrative data. Participants may not have responded to first-line treatment or have contraindications resulting in a PIM being prescribed or an indicated medicine being omitted. Prescribers may have to weigh up the incremental benefit of one additional indicated medicine against increasing the treatment burden in older patients already taking multiple medications. The structure of the health system in Ireland, in particular the lack of implementation of a co-ordinated chronic disease management policy across primary and secondary care, may also contribute to the rate of PIP, and future implementation of this policy could have a positive impact on prescribing .
The strength of evidence of inappropriateness varies across criteria and the risk-benefit ratio may have changed since PIP screening tools were developed. For example, aspirin for primary prevention is included in STOPP, but evidence is conflicting on the net benefit in people with cardiovascular risk factors but without previous cardiovascular events/symptoms [32, 33].
A high proportion of study participants have both prescribing errors of commission (PIMs) and omission (PPOs). This suggests that reviewing both suitability of current medicines and assessing the need for additional indicated therapies is necessary to optimise prescribing for older people.
The long-term prescription of full therapeutic dosage PPIs has been identified previously as a particularly common issue in older people and represents a significant cost burden . Though the cost-effective use of PPIs in Ireland has been promoted through policies such as reference pricing and preferred drug schemes, a focus on prescribing appropriate dosages and durations may provide clinical benefits to patients as well as cost savings [35, 36]. Although long-term benzodiazepine use declined in this study, this may be explained by substitution with Z-drug hypnotics which showed a non-significant increase in prevalence. Omission of antihypertensive therapy also declined at follow-up, which may have been due to participants with high blood pressure at baseline interview being advised to discuss this with their general practitioner.
Strengths and limitations of the study
This study’s participants are community-dwelling older people from a nationally representative study on ageing, which improves the generalisability of these findings. Although only participants with eligibility to the means-tested GMS scheme were included, a high proportion (73.5 %) of TILDA participants aged over 65 reported GMS eligibility (see Fig. 1).
The use of administrative pharmacy claims data in this study may provide more accurate information on medication exposure than self-reported medication use, although good agreement has been found between such sources . It also allows medication exposure to be determined over a 12-month time period to provide a more accurate assessment of PIM and PPO prevalence, as opposed to using medication data from one point in time which could underestimate PIMs and overestimate PPOs.
A limitation of pharmacy claims data is that patients may not have actually consumed medications dispensed (i.e. if patients are non-adherent), and a lack of information on medicines purchased over-the-counter may lead to an overestimation of some prescribing omissions (e.g. calcium and vitamin D, laxatives). Additionally, there may have been a clinical reason why some participants had a PIM/PPO; however, as no clinical notes were available, it is not possible to determine clinicians’ rationale for such prescribing decisions.
A number of criteria from each of the PIM and PPO screening tools could not be included in this analysis due to the required information not being available in the administrative and survey data used. However, the combination of these data sources allows for a greater number of criteria to be applied than with either source alone . Some information on diagnoses was based on participants self-report and so may not accurately reflect the presence/absence of the conditions of interest.
Although prevalence of PIMs and PPOs can vary depending on the screening tool used, such prescribing issues are common and may become more prevalent in patients with more medicines or chronic illnesses. This underlines the importance of ongoing prescribing review for older patients, both to assess the appropriateness of current drug therapy as well as to evaluate the need for additional clinically indicated treatments. Further research is planned to examine the association between potentially inappropriate prescribing over time and adverse health outcomes.
This research was funded by the Health Research Board (HRB) through the HRB PhD Scholars Programme in Health Services Research under Grant no. PHD/2007/16 and the HRB Centre for Primary Care Research under Grant no HRC/2007/1. TILDA was supported by Department of Health and Children, The Atlantic Philanthropies and Irish Life. We wish to thank the Health Services Executive Primary Care Reimbursement Services (HSE-PCRS) for the use of the prescribing database and Kathryn Richardson for her assistance in linking data for the study participants.
Conflict of interest
The authors declare that they have no conflict of interest.
FM, KB, TF and CC planned and designed this study. Acquisition of data was carried out by RAK (TILDA) and KB (HSE-PCRS). FM and CC performed data linkage and analysis. FM drafted the manuscript, and KB, TF, RAK and CC critically reviewed and approved the final manuscript.
Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.