Geographical differences in the prevalence of chronic polypharmacy in older people: eleven years of the EPIFARM-Elderly Project
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
To compare the geographical differences in the prevalence of chronic polypharmacy in community-dwelling older people over 11 years.
This study analyzed nearly two million patients aged 65–94 years recorded in the Drug Administrative Database of the Lombardy Region (Northern Italy) from 2000 to 2010. Chronic polypharmacy was defined as taking five or more drugs in 1 month for at least 6 months (consecutive or not) in a year.
There was a significant spatial autocorrelation that increased at the municipality level from 2000 (Moran’s I Index = 0.26, z score = 16.91, p < 0.0001) to 2010 (Moran’s I Index = 0.36, z score = 23.78, p < 0.0001). Clusters of high (Z(G) > 1.96) and low (Z(G) < −1.96) prevalence rates of chronic polypharmacy were found and were not influenced by age. Chronic polypharmacy weakly correlated with hospital admission (2000: ρ = 0.08, p = 0.0032; 2005: ρ = 0.11, p < 0.0001; 2010: ρ = 0.18, p < 0.0001), but not with mortality.
There were geographical differences in the prevalence of older people with chronic polypharmacy that were only partly explained by health indicators. Targeted activities on prescription practice to ensure that the prescribing of chronic polypharmacy is appropriate are required.
- Geographical differences in the prevalence of chronic polypharmacy in older people: eleven years of the EPIFARM-Elderly Project
European Journal of Clinical Pharmacology
Volume 69, Issue 7 , pp 1477-1483
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Older people
- Chronic polypharmacy
- Geographical difference
- Industry Sectors
- Author Affiliations
- 1. Laboratory for Quality Assessment of Geriatric Therapies and Services, Istituto di Ricerche Farmacologiche Mario Negri-IRCCS, Via Giuseppe La Masa, 19, 20156, Milan, Italy
- 2. Laboratory of Mother and Child Health, Istituto di Ricerche Farmacologiche Mario Negri-IRCCS, Milan, Italy
- 3. Laboratory of Epidemiology and Social Psychiatry, Istituto di Ricerche Farmacologiche Mario Negri-IRCCS, Milan, Italy
- 4. IRCCS Maggiore Hospital Foundation and University of Milan, Department of Clinical Sciences and Community Health, Geriatric Unit, Milan, Italy
- 5. Laboratory of Geriatric Neuropsychiatry, Istituto di Ricerche Farmacologiche Mario Negri-IRCCS, Milan, Italy
- 6. Regional Health Ministry, Lombardy Region, Milan, Italy