European Journal of Clinical Pharmacology

, Volume 66, Issue 3, pp 219–230

Stimulation of endothelial progenitor cells: a new putative effect of several cardiovascular drugs

  • Natália António
  • Rosa Fernandes
  • Noela Rodriguez-Losada
  • Manuel F. Jiménez-Navarro
  • Artur Paiva
  • Eduardo de Teresa Galván
  • Lino Gonçalves
  • Carlos Fontes Ribeiro
  • Luís A. Providência
Review Article

DOI: 10.1007/s00228-009-0764-y

Cite this article as:
António, N., Fernandes, R., Rodriguez-Losada, N. et al. Eur J Clin Pharmacol (2010) 66: 219. doi:10.1007/s00228-009-0764-y

Abstract

The role of vascular endothelium in cardiovascular disorders is well recognized. Mature endothelial cells contribute to the repair of endothelial injury, but they only have a limited capacity to do so. This has led to growing interest and further investigation into circulating endothelial progenitor cells (EPCs) and their role in vascular healing, repair, and postnatal neovascularization. The current perception of vascular health is that of a balance between ongoing injury and resultant vascular repair, mediated at least in part by circulating EPCs. Circulating EPCs play an important role in accelerating endothelialization at areas of vascular damage, and EPC enumeration is a viable strategy for assessing reparative capacity. Recent studies have shown that EPCs are affected both in number and function by several cardiovascular risk factors as well as various cardiovascular disease states, such as hypertension, hypercholesterolemia, and coronary artery disease. The present review summarizes the most relevant studies on the effects of cardiovascular drugs on vascular function and EPCs, focusing on their mechanisms of action.

Keywords

Cardiovascular disease Drugs Endothelial dysfunction Endothelial progenitor cells Neovascularization 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Natália António
    • 1
    • 2
    • 5
  • Rosa Fernandes
    • 2
  • Noela Rodriguez-Losada
    • 3
  • Manuel F. Jiménez-Navarro
    • 3
  • Artur Paiva
    • 4
  • Eduardo de Teresa Galván
    • 3
  • Lino Gonçalves
    • 1
  • Carlos Fontes Ribeiro
    • 2
  • Luís A. Providência
    • 1
  1. 1.Cardiology DepartmentCoimbra University Hospital and Medical SchoolCoimbraPortugal
  2. 2.Faculty of MedicineInstitute of Pharmacology and Experimental Therapeutics–Biomedical Institute for Research in Light and Image (IBILI), Coimbra UniversityCoimbraPortugal
  3. 3.Research Laboratory, Heart UnitVirgen de la Victoria University HospitalMalagaSpain
  4. 4.Flow Cytometry LaboratoryHistocompatibility Center of CoimbraCoimbraPortugal
  5. 5.Serviço de CardiologiaHospitais da Universidade de CoimbraCoimbraPortugal