European Journal of Clinical Pharmacology

, Volume 58, Issue 7, pp 479–482

Drug-related deaths in a university central hospital

  •  L. Juntti-Patinen
  •  P. Neuvonen
Pharmacoepidemiology and Prescription

DOI: 10.1007/s00228-002-0501-2

Cite this article as:
Juntti-Patinen, L. & Neuvonen, P. Eur J Clin Pharmacol (2002) 58: 479. doi:10.1007/s00228-002-0501-2


Objectives. The objectives were to determine the incidence of drug-related deaths in a university hospital and to find out which drugs are most commonly involved in these cases.

Methods. The files of 1511 death cases (97.7% of all death cases in the Helsinki University Central Hospital during the year 2000) were scrutinised. In the cases of suspected drug-related deaths excluding suicides, the medication, its duration and indications, the route of drug administration, and the type of the adverse reactions were determined. The probability of a fatal adverse drug reaction was classified according to WHO's classification. In addition, the incidence of drug-related deaths was calculated from the death certificates.

Results. Scrutiny of the patients' files showed that 75 of the death cases (5.0% of all deaths) were certainly or probably drug-related. This corresponds to about 0.05% of all hospital admissions. The most common adverse reactions were neutropenia caused by antineoplastic agents and gastrointestinal or intracranial haemorrhage due to anticoagulants or nonsteroidal anti-inflammatory drugs (NSAIDs). The incidence of drug-related deaths is only 0.5% when based on the International Classification of Diseases (ICD) codes in death certificates.

Conclusions. Adverse drug reaction is a significant cause of death. Most of the deaths occurred in seriously ill patients with high-risk medication and they are seldom preventable. Incidence figures based on death certificates only may seriously underestimate the true incidence of fatal adverse reactions.

Adverse drug reaction Drug-related death Antineoplastic agents Anticoagulants 

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  •  L. Juntti-Patinen
    • 1
  •  P. Neuvonen
    • 1
  1. 1.Department of Clinical Pharmacology, Helsinki University Central Hospital, P.O. Box 340, 00029 HUS, Helsinki, Finland

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