European Journal of Clinical Pharmacology

, Volume 58, Issue 2, pp 115–118

N-acetyltransferase 2 single-nucleotide polymorphisms and risk of gastric carcinoma

  • José M. Ladero
  • José A. Agúndez
  • Manuela Olivera
  • Luis Lozano
  • Alvaro Rodríguez-Lescure
  • Manuel Diaz-Rubio
  • Julio Benítez
Pharmacokinetics and Disposition

DOI: 10.1007/s00228-002-0460-7

Cite this article as:
Ladero, J.M., Agúndez, J.A., Olivera, M. et al. Eur J Clin Pharmacol (2002) 58: 115. doi:10.1007/s00228-002-0460-7

Abstract

Objective. To explore whether an association exists between the NAT2 genotype and the risk of developing gastric cancer.

Methods. Ninety-nine patients with gastric adenocarcinoma and 258 healthy subjects were analysed for single-nucleotide polymorphisms at the NAT2 gene locus, which give rise to gene variants known to be associated with slow-acetylation status.

Results. The functional NAT2*4 (wild-type) allele is over-represented among patients (40.4% of all allelic variants) compared with control subjects [25.8%, odds ratio (OR) 1.95, 95% confidence interval (CI) 1.36, 2.8]. According to the NAT2 genotype, 69 patients (69.9%) and 119 healthy subjects (46%) were classified as rapid acetylators (OR 2.69, 95% CI 1.6, 4.54).

Conclusions. Our results, which need independent confirmation, suggest that individuals with NAT2 genotypes leading to high levels of NAT2 enzyme activity are at increased risk of developing gastric carcinoma.

Gastric cancer N-acetyltransferase 2 Carcinogenesis 

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • José M. Ladero
    • 1
  • José A. Agúndez
    • 3
  • Manuela Olivera
    • 3
  • Luis Lozano
    • 3
  • Alvaro Rodríguez-Lescure
    • 2
  • Manuel Diaz-Rubio
    • 1
  • Julio Benítez
    • 3
  1. 1.Gastroenterology Service, Hospital Clínico San Carlos, Medical School, Universidad Complutense, MadridSpain
  2. 2.Oncology Service, Hospital del Insalud, Elche, AlicanteSpain
  3. 3.Department of Pharmacology, Medical School, Universidad de Extremadura, BadajozSpain
  4. 4.Servicio de Aparato Digestivo, Hospital Clínico San Carlos, C/Martin Lagos s/n, Ciudad Universitaria, 28040 MadridSpain

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