N-acetyltransferase 2 single-nucleotide polymorphisms and risk of gastric carcinoma
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- Ladero, J.M., Agúndez, J.A., Olivera, M. et al. Eur J Clin Pharmacol (2002) 58: 115. doi:10.1007/s00228-002-0460-7
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Objective. To explore whether an association exists between the NAT2 genotype and the risk of developing gastric cancer.
Methods. Ninety-nine patients with gastric adenocarcinoma and 258 healthy subjects were analysed for single-nucleotide polymorphisms at the NAT2 gene locus, which give rise to gene variants known to be associated with slow-acetylation status.
Results. The functional NAT2*4 (wild-type) allele is over-represented among patients (40.4% of all allelic variants) compared with control subjects [25.8%, odds ratio (OR) 1.95, 95% confidence interval (CI) 1.36, 2.8]. According to the NAT2 genotype, 69 patients (69.9%) and 119 healthy subjects (46%) were classified as rapid acetylators (OR 2.69, 95% CI 1.6, 4.54).
Conclusions. Our results, which need independent confirmation, suggest that individuals with NAT2 genotypes leading to high levels of NAT2 enzyme activity are at increased risk of developing gastric carcinoma.