Calcified Tissue International

, Volume 65, Issue 2, pp 121–124

The Urinary Excretion of Deoxypyridinium Cross-Links is Higher in Diabetic Than in Nondiabetic Adolescents

  • M.  Bjørgaas
  • E.  Haug
  • H. J.  Johnsen

DOI: 10.1007/s002239900668

Cite this article as:
Bjørgaas, M., Haug, E. & Johnsen, H. Calcif Tissue Int (1999) 65: 121. doi:10.1007/s002239900668

Abstract.

We have measured the urinary excretion of deoxypyridinium (D-Pyr) crosslinks, a sensitive and specific marker of bone resorption, in morning urine in 102 healthy, nonhospitalized, Caucasian subjects (8–18 years) and in 18 diabetic subjects (12–17 years). The free D-Pyr crosslinks were measured using the Pyrilinks D-Assay. In the diabetic subjects, plasma glucose was regulated throughout the night by a constant infusion of insulin and a variable infusion of 24% glucose. In the nondiabetic subjects, the excretion of D-Pyr increased until 12–14 years of age, and thereafter decreased, and the excretion of D-Pyr/hour was correlated with the height Z-score. The excretion of D-Pyr/hour and the D-Pyr/creatinine ratio was higher in the diabetic adolescents than in the nondiabetic adolescents. In subjects over the age of 12, the D-pyr/creatinine ratio was higher in males than in females. In conclusion, in healthy children and adolescents, the excretion of D-Pyr peaks at 12–14 years of age. The D-Pyr excretion is higher in diabetic than in nondiabetic adolescents, suggesting increased bone resorption in diabetic adolescents.

Key words: Adolescence — Bone resorption — Deoxypyridinium crosslinks — Diabetes mellitus.

Copyright information

© 1999 Springer-Verlag New York Inc.

Authors and Affiliations

  • M.  Bjørgaas
    • 1
  • E.  Haug
    • 2
  • H. J.  Johnsen
    • 1
  1. 1.Department of Clinical Chemistry, University Hospital of Trondheim, N-7006 Trondheim, NorwayNO
  2. 2.Hormone Laboratory, Aker University Hospital, Oslo, NorwayNO