Calcified Tissue International

, Volume 60 , Issue 4 , pp 391 –393

Longitudinal Overgrowth of Bone After Osteotomy in Young Rats: Influence of Bone Stability

  • G. L.  Garcés
  • J. M.  García-Castellano
  • J.  Nogales

DOI: 10.1007/s002239900249

Cite this article as:
Garcés, G., García-Castellano, J. & Nogales, J. Calcif Tissue Int (1997) 60: 391. doi:10.1007/s002239900249

Abstract.

One hundred and five 5-week-old male rats were used to study the influence of the stability of an osteotomy on longitudinal overgrowth of the bone. In 45 rats (Group 1) a transverse diaphyseal osteotomy of the right tibia was made; the left tibia was left untreated. In the second 45 rats (Group 2) the right tibia was osteotomized after applying an external fixator; the left tibia underwent a sham operation without osteotomy. Fifteen further rats (Group 3) were used as a nonoperated control group. After being measured at different periods up to 20 weeks, the osteotomized tibiae of the Group 1 (unstable) were 16–25% longer than those of their nontreated limbs (P < 0.001). The osteotomized tibiae of the Group 2 (stable) were 6–11% longer than those of the sham-operated opposite limbs (P < 0.001). The osteotomized and unstable tibiae were 9–17% longer than the osteotomized and stable tibiae (P < 0.001) throughout the whole study. Although several factors have been considered to be responsible for longitudinal bone overgrowth after fracture in young animals, this work suggests that bone's stability plays a decisive role in the final outcome.

Key words: Bone growth — Fractures — Osteotomy.

Copyright information

© 1997 Springer-Verlag New York Inc.

Authors and Affiliations

  • G. L.  Garcés
    • 1
  • J. M.  García-Castellano
    • 1
  • J.  Nogales
    • 1
  1. 1.Instituto Canario de Ortopedia Traumatología, University of Las Palmas de Gran Canaria, Las Palmas SpainES