Calcified Tissue International

, Volume 59, Issue 5, pp 328–333

Biochemical Markers of Bone Turnover Reflect Femoral Bone Loss in Elderly Women

  • R.  Dresner-Pollak
  • R. A.  Parker
  • M.  Poku
  • J.  Thompson
  • M. J.  Seibel
  • S. L.  Greenspan
Article

DOI: 10.1007/s002239900135

Cite this article as:
Dresner-Pollak, R., Parker, R., Poku, M. et al. Calcif Tissue Int (1996) 59: 328. doi:10.1007/s002239900135

Abstract.

Although over 90% of hip fractures occur in patients over age 70, few data are available on femoral bone loss in this age group. To examine the relationship between biochemical markers of bone turnover and femoral bone loss in the elderly, 36 female and 17 male, healthy, community-dwelling elderly over age 65 (mean ± SD age: women 71 ± 4 years, men 75 ± 5 years) were followed for 3 years. Annual bone mineral density measurements of the hip and lumbar spine by dual-energy x-ray absorptiometry (DXA) were obtained and biochemical markers of bone resorption (urinary N-telopeptide crosslinks, free pyridinoline, total pyridinoline, total deoxypyridinoline, and hydroxyproline) and bone formation (serum osteocalcin, bone-specific alkaline phosphatase) were obtained at the end of year 3. In elderly women, longitudinal bone loss at the total hip was negatively correlated with markers of bone resorption (r =−0.39 to −0.52, P < 0.05), bone formation (r =−0.38, P < 0.05), and age (r =−0.39, P < 0.05). Markers of bone resorption were correlated with markers of bone formation (r = 0.63 to 0.74, P < 0.01). In multiple regression analysis, urinary N-telopeptide crosslinks (marker of resorption), serum osteocalcin (marker of formation), and serum parathyroid hormone explained 43% of the variability of bone loss at the total hip in women. These parameters were not related to bone loss in men. We conclude that femoral bone loss increases with age in women over 65. Measurements of specific biochemical markers of bone turnover are correlated with longitudinal bone loss in elderly women. These markers may help identify women at greatest risk for bone loss who would benefit most from therapeutic interventions.

Key words: Osteoporosis — Elderly women — Biochemical markers — Bone loss — DXA.

Copyright information

© Springer-Verlag New York Inc. 1996

Authors and Affiliations

  • R.  Dresner-Pollak
    • 1
  • R. A.  Parker
    • 4
  • M.  Poku
    • 1
  • J.  Thompson
    • 1
  • M. J.  Seibel
    • 5
  • S. L.  Greenspan
    • 1
  1. 1.Division of Bone and Mineral Metabolism, Beth Israel Hospital, 330 Brookline Avenue, GZ-800, Boston, MassachusettsUS
  2. 2.Division of Gerontology, Beth Israel Hospital, Boston, MassachusettsUS
  3. 3.Division of Endocrinology, Beth Israel Hospital, Boston, MassachusettsUS
  4. 4.The Charles A. Dana Research Institute and Harvard-Thorndike Laboratories, Beth Israel Hospital and Harvard Medical SchoolUS
  5. 5.Division of Endocrinology and Metabolism, University of Heidelberg, Heidelberg, GermanyDE
  6. 6.Biometrics Center, Beth Israel Hospital, Boston, MassachusettsUS