Abstract
This study estimates the risk of symptomatic nephrolithiasis within 5 years of newly diagnosed osteoporosis in a Taiwan population. This cohort study consisted of patients with a diagnosis of osteoporosis between Jan. 2003 and Dec. 2005 (N = 1634). Four age- and gender- matched patients for every patient in the study cohort were selected using random sampling as the comparison cohort (N = 6536). All patients were tracked for 5 years from the date of cohort entry to identify whether they developed symptomatic nephrolithiasis. Cox proportional hazard regressions were performed to evaluate the 5-year nephrolithiasis-free survival rates. During the 5-year follow-up period, 60 osteoporosis patients (3.7 %) and 165 non- osteoporosis patients (2.5 %) developed symptomatic nephrolithiasis. The adjusted HR of symptomatic nephrolithiasis was 1.38 times greater risk for patients with osteoporosis than for the comparison cohort (95% confidence interval (CI) 1.03–1.86; P < .05). Osteoporosis is very likely to be an independent risk factor for subsequent diagnosis of symptomatic nephrolithiasis.
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Acknowledgments
This study was partially supported by grants from the Comprehensive Cancer Center of Taipei Medical University (MOHW103-TD-B-111-01), National Science Council, Taiwan, NSC 102-2314-B-037-058 and National Science Council, Taiwan, MOST 103-2410-H-264-004.
Human and Animal Rights and Informed Consent
This study was conducted in accordance with the Helsinki Declaration. A formal waiver was received from the institutional review board (IRB) of Taipei Medical University (TMU-JIRB NO. 201306039).
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The authors declare that there are no financial or other conflicts of interest in connection with this paper.
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Chou, PS., Kuo, CN., Hung, KS. et al. Osteoporosis and the Risk of Symptomatic Nephrolithiasis: A Population-Based 5-Year Follow-Up Study in Taiwan. Calcif Tissue Int 95, 317–322 (2014). https://doi.org/10.1007/s00223-014-9895-y
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DOI: https://doi.org/10.1007/s00223-014-9895-y