Calcified Tissue International

, Volume 92, Issue 4, pp 394–398

Antiretroviral Therapy and Pregnancy: Effect on Cortical Bone Status of Human Immunodeficiency Virus–Infected Caucasian Women as Assessed by Quantitative Ultrasonography

  • Stefano Mora
  • Cecilia Diceglie
  • Alessandra Viganò
  • Vania Giacomet
  • Valeria Manfredini
  • Sara Stucchi
  • Valentina Fabiano
  • Chiara Mameli
  • Sonia Coletto
  • Gian V. Zuccotti
Original Research

DOI: 10.1007/s00223-013-9696-8

Cite this article as:
Mora, S., Diceglie, C., Viganò, A. et al. Calcif Tissue Int (2013) 92: 394. doi:10.1007/s00223-013-9696-8
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Abstract

Treatment with antiretroviral agents (ARVs) during pregnancy is important to prevent mother-to-child transmission of the human immunodeficiency virus (HIV), but their use has been associated with low bone mineral density in adult patients. Currently, there are no data regarding the bone status of HIV-infected women who received ARV during pregnancy. The aim of this study was to evaluate cortical bone status at delivery in a group of HIV-infected women who received ARV during pregnancy and to monitor the changes occurring during the first year postpartum. We studied 33 HIV-infected and 116 HIV-uninfected healthy Caucasian women within 4 days from delivery. Follow-up measurements were performed at 4 and 12 months postpartum in 17 HIV-infected and 55 healthy women. Cortical bone status was evaluated by quantitative ultrasonography at the mid-tibia, and bone measurements were expressed as the speed of sound (SOS). HIV-infected women after delivery had a median SOS of 3,985 (3,567–4,242) m/s, while the median SOS of healthy women was 4,025 (3,643–4,250) m/s. The difference was not significant (t = 0.39, P = 0.69). No significant differences were observed between ARV-exposed and control subjects at 4 and 12 months. Our data suggest that ARV during pregnancy and the first year after delivery does not affect negatively cortical bone status.

Keywords

Antiretroviral therapy Bone mass HIV infection Pregnancy Quantitative ultrasonography 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Stefano Mora
    • 1
  • Cecilia Diceglie
    • 1
  • Alessandra Viganò
    • 2
  • Vania Giacomet
    • 2
  • Valeria Manfredini
    • 2
  • Sara Stucchi
    • 2
  • Valentina Fabiano
    • 2
  • Chiara Mameli
    • 2
  • Sonia Coletto
    • 2
  • Gian V. Zuccotti
    • 2
  1. 1.Laboratory of Pediatric Endocrinology, BoNetwork, Division of Metabolic and Cardiovascular SciencesSan Raffaele Scientific InstituteMilanItaly
  2. 2.Department of PediatricsL. Sacco Hospital, University of MilanMilanItaly