Calcified Tissue International

, Volume 77, Issue 3, pp 152–159

Genetic Polymorphisms of OPG, RANK, and ESR1 and Bone Mineral Density in Korean Postmenopausal Women

  • J. Y. Choi
  • A. Shin
  • S. K. Park
  • H. W. Chung
  • S.I. Cho
  • C. S. Shin
  • H. Kim
  • K. M. Lee
  • K. H. Lee
  • C. Kang
  • D. Y. Cho
  • D. Kang
Article

DOI: 10.1007/s00223-004-0264-0

Cite this article as:
Choi, J.Y., Shin, A., Park, S.K. et al. Calcif Tissue Int (2005) 77: 152. doi:10.1007/s00223-004-0264-0

Abstract

To evaluate the effects of genetic polymorphisms of OPG, RANK, and ESR1, which regulate osteoclastogenesis, on bone mineral density (BMD), a cross-sectional study was conducted in 650 Korean postmenopausal women. BMDs of the distal radius and the calcaneus were measured by dual energy X-ray absorptiometry (DXA). Genetic polymorphisms of OPG 163 A > G, 1181 G > C; RANK 421 C > T, 575 T > C; and ESR1 1335 C > T, 2142 G > A were determined by matrix-assisted laser desorption/ionization—time of flight (MALDI-ToF) mass spectrometry. The differences between the BMDs of the genotypes of OPG, RANK, and ESR1 were analyzed by multiple linear regression model adjusted for age and body mass index. Women with the OPG 1181 CC genotype had higher BMDs at the distal radius (7%) and calcaneus (10%) than those with the GG genotype; and these differences were statistically significant (P = 0.001 and P = 0.007, respectively). A significant association was also observed between RANK 575 T > C and calcaneus BMD (P for trend = 0.017). No significant association was observed between BMDs and the polymorphisms of ESR1. The association between OPG 1181 G > C and BMD was profound in subjects with the RANK 575 TT or ESR1 2142 GG genotypes; women with OPG 1181 CC had higher BMDs at the distal radius (11%) and calcaneus (11%) than those with OPG 1181 GG only in women with RANK 575 TT genotype (P = 0.002 and P = 0.021, respectively). These results suggest that OPG genetic polymorphisms, especially with the RANK 575 TT or ESR1 2142 GG genotypes, are related to low BMD in postmenopausal Korean women.

Key words

OPG-RANKBone mineral densityGenetic polymorphism

Copyright information

©  Springer Science+Business Media, Inc.  2005

Authors and Affiliations

  • J. Y. Choi
    • 1
  • A. Shin
    • 2
  • S. K. Park
    • 3
  • H. W. Chung
    • 4
  • S.I. Cho
    • 5
  • C. S. Shin
    • 6
  • H. Kim
    • 5
  • K. M. Lee
    • 1
  • K. H. Lee
    • 1
  • C. Kang
    • 7
  • D. Y. Cho
    • 8
  • D. Kang
    • 1
    • 9
  1. 1.Department of Preventive Medicine Seoul National University College of MedicineSeoulKorea
  2. 2.Center for Health Services ResearchVanderbilt UniversityUSA
  3. 3.Department of Preventive Medicine Konkuk University College of Medicine ChungjuKorea
  4. 4.Department of Obstetrics and Gynecology Ewha Womans University College of MedicineKorea
  5. 5.Department of Epidemiology and Biostatistics and Institute of Public health and Enviornmental Sciences, School of Public Health Seoul National UniversitySouth Korea
  6. 6.Department of Internal Medicine Seoul National University College of MedicineKorea
  7. 7.Department of Biological ScienceKAISTKorea
  8. 8.Clinical Research Institute Labgenomics Co., LtdKorea
  9. 9.Cancer Research Institute Seoul National University College of MedicineKorea