Calcified Tissue International

, Volume 74, Issue 6, pp 501–508

Estrogen Receptor β Dinucleotide (CA) Repeat Polymorphism is Significantly Associated with Bone Mineral Density in Postmenopausal Women

  • J. K. Scariano
  • S. G. Simplicio
  • G. D. Montoya
  • P. J. Garry
  • R. N. Baumgartner
Article

DOI: 10.1007/s00223-003-0170-x

Cite this article as:
Scariano, J.K., Simplicio, S.G., Montoya, G.D. et al. Calcif Tissue Int (2004) 74: 501. doi:10.1007/s00223-003-0170-x

Abstract

Significant associations between the lengths of a highly polymorphic dinucleotide (CA) repeat located within the human estrogen receptor beta (ESR2) gene on chromosome 14, bone mineral density (BMD) and androgen levels have been reported previously in premenopausal women. We measured the size of this microsatellite repeat in 226 healthy women (60–98 years). After adjustment for age, body mass index, hormone replacement status, and other variables known to influence BMD, women with <25 CA repeats had significantly higher BMD measured in the total skeleton, lumbar spine, and femoral neck when compared with women having longer alleles. Women with shorter alleles also had higher circulating estrone and estradiol levels that approached statistical significance as compared with women harboring longer alleles after appropriate adjustments were performed in linear regression models. Women having both short and long CA repeats had BMD values in all regions of the skeleton that were midway between those found in women homozygous for longer or shorter repeat sizes. Because the ESR2 CA repeat size was neither associated with change in BMD nor serum levels of biochemical markers of bone turnover, it is likely that ESR2 CA repeat genotype is significantly linked to the attainment of peak bone mass in women.

Keywords

Estrogen receptor betaEstrogen receptor 2 (ESR2)PolymorphismBone mineral densityElderly womenOsteoporosisOsteopenia

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • J. K. Scariano
    • 1
  • S. G. Simplicio
    • 2
  • G. D. Montoya
    • 3
  • P. J. Garry
    • 2
    • 3
  • R. N. Baumgartner
    • 2
  1. 1.Department of PathologyMedical Laboratory Sciences, MSC09 5250, 1 University of New MexicoAlbuquerqueUSA
  2. 2.Aging and Genetic Epidemiology, Department of Internal MedicineUniversity of New Mexico School of MedicineAlbuquerqueUSA
  3. 3.Department of PathologyUniversity of New Mexico School of MedicineAlbuquerqueUSA