Calcified Tissue International

, Volume 74, Issue 5, pp 424–428

Quantitative Ultrasound Measurements in Children and Adolescents with: Type 1 Diabetes

  • J. Damilakis
  • E. Galanakis
  • D. Mamoulakis
  • S. Sbyrakis
  • N. Gourtsoyiannis
Article

DOI: 10.1007/s00223-003-0164-8

Cite this article as:
Damilakis, J., Galanakis, E., Mamoulakis, D. et al. Calcif Tissue Int (2004) 74: 424. doi:10.1007/s00223-003-0164-8

Abstract

The aim of the current study was to evaluate bone status at the radius and phalanx in children and adolescents with type 1 diabetes by using quantitative ultrasound (QUS) measurements. Thirty pediatric patients, 16 male and 14 female, with type 1 diabetes of duration of 5 to 177 months and mean (± SD) age 11.3 ± 4.6 years were studied. QUS measurements were carried out using the Sunlight Omnisense 7000 S device. Speed of sound (SOS) was measured at the radius and tibia. Diabetic control was assessed by glycosylated hemoglobin (HbA1c) measurements. Male and female patients with type 1 diabetes did not have significantly different SOS or HbA1c values. SOS Z-scores at both the radius and tibia were negatively associated with duration of disease (r = −0 41 and r = −0.37 for the radius and tibia respectively, P < 0.05 for both correlations). Seven of 15 patients with duration of disease of >6 years had diminished SOS, defined as Z-score of <−1, at either the radius or tibia. SOS measurements at the radius showed moderate correlation with SOS at the tibia (r = 0.58, P < 0.00 l). There was no correlation between SOS and HbA1c. In conclusion, SOS Z-scores at both the radius and tibia show a significant negative correlation with duration of insulin-dependent diabetes in children. No relation was found between SOS and metabolic control of young diabetic patients.

Keywords

Insulin-dependent diabetes Pediatrics Quantitative ultrasound Speed of sound Osteoporosis 

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • J. Damilakis
    • 1
    • 4
  • E. Galanakis
    • 2
  • D. Mamoulakis
    • 2
  • S. Sbyrakis
    • 2
  • N. Gourtsoyiannis
    • 3
  1. 1.Department of Medical PhysicsUniversity of CreteIraklionGreece
  2. 2.Department of PediatricsUniversity Hospital of IraklionGreece
  3. 3.Department of RadiologyUniversity of CreteIraklionGreece
  4. 4.Department of Medical PhysicsUniversity of Crete, Faculty of MedicineIraklionGreece