Clinical Investigations

Calcified Tissue International

, Volume 72, Issue 6, pp 681-688

Influence of Age, Sex, and Growth Variables on Phalangeal Quantitative Ultrasound Measures: A Study in Healthy Children and Adolescents

  • M. VignoloAffiliated withI Clinica Pediatrica, Dipartimento di Pediatria, Università di Genova, Istituto G. Gaslini, Genova Email author 
  • , A. BrignoneAffiliated withI Clinica Pediatrica, Dipartimento di Pediatria, Università di Genova, Istituto G. Gaslini, Genova
  • , A. MascagniAffiliated withI Clinica Pediatrica, Dipartimento di Pediatria, Università di Genova, Istituto G. Gaslini, Genova
  • , G. RaveraAffiliated withIstituto di Statistica, Università di Genova, Genova
  • , B. BiasottiAffiliated withIstituto di Statistica, Università di Genova, Genova
  • , G. AicardiAffiliated withI Clinica Pediatrica, Dipartimento di Pediatria, Università di Genova, Istituto G. Gaslini, Genova

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Abstract

Skeletal status by phalangeal quantitative osteosonography (DBM Sonic BP - IGEA) was examined in 1227 healthy children (641 boys and 586 girls) aged 3–16 years. Aims of the study were to evaluate some physical parameters pertaining to the ultrasound transmission crossing the phalanx in a school-age population and to relate these values to age, sex, and growth variables. A correlation was found between AD-SoS (amplitude-dependent speed of sound) and BTT (bone transmission time) and, age, height, weight, and pubertal stage, respectively. No correlation existed between FWA (fast wave amplitude) and SDy (dynamics of the ultrasound signal) and age, height, weight, pubertal stage, and BMI, respectively. AD-SoS increased in boys until 7–8 years of age. Thereafter a plateau was reached up to age 12–13 years, when a rapid increase was observed corresponding to pubertal growth rate acceleration. In girls, AD-SoS increased with age up to 10–11 years with a steeper increase at the time of puberty starting about 2 years earlier than in boys. BTT presented a similar trend. Mean AD-SoS values increased from Tanner pubertal stages 1 to 2 and from stage 3 to 4 in both sexes. Significantly higher mean AD-SoS values in stages 2, 3, and 4 were observed in girls as compared to boys. Mean BTT values increased significantly from stage 1 to 5 in girls and from 1 to 4 in boys. QUS technology showed the ability to assess bone changes in the growing bone.

Keywords

Quantitative ultrasonography (QUS) Growth Skeletal development