Experimental Brain Research

, Volume 138, Issue 4, pp 403–409

Functional mapping of human medial frontal motor areas

The combined use of functional magnetic resonance imaging and cortical stimulation
  • Takashi Hanakawa
  • Akio Ikeda
  • Norihiro Sadato
  • Tomohisa Okada
  • Hidenao Fukuyama
  • Takashi Nagamine
  • Manabu Honda
  • Nobukatsu Sawamoto
  • Shogo Yazawa
  • Takeharu Kunieda
  • Shinji Ohara
  • Waro Taki
  • Nobuo Hashimoto
  • Yoshiharu Yonekura
  • Junji Konishi
  • Hiroshi Shibasaki
Research Article

DOI: 10.1007/s002210100727

Cite this article as:
Hanakawa, T., Ikeda, A., Sadato, N. et al. Exp Brain Res (2001) 138: 403. doi:10.1007/s002210100727

Abstract.

Two functional brain-mapping techniques, functional magnetic resonance imaging (fMRI) and cortical stimulation by chronically implanted subdural electrodes, were used in combination for presurgical evaluation of three patients with intractable, partial motor seizures. Brain mapping was focused on characterizing motor-related areas in the medial frontal cortex, where all patients had organic lesions. Behavioral tasks for fMRI involved simple finger and foot movements in all patients and mental calculations in one of them. These tasks allowed us to discriminate several medial frontal motor areas: the presupplementary motor areas (pre-SMA), the somatotopically organized SMA proper, and the foot representation of the primary motor cortex. All patients subsequently underwent cortical stimulation through subdural electrodes placed onto the medial hemispheric wall. In each patient, the cortical stimulation map was mostly consistent with that patient's brain map by fMRI. By integrating different lines of information, the combined fMRI and cortical stimulation map will contribute not only to safe and effective surgery but also to further understanding of human functional neuroanatomy.

Epilepsy Brain mapping Supplementary motor areas Somatotopy Mental calculations Human

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Takashi Hanakawa
    • 1
  • Akio Ikeda
    • 1
  • Norihiro Sadato
    • 3
  • Tomohisa Okada
    • 2
  • Hidenao Fukuyama
    • 1
  • Takashi Nagamine
    • 1
  • Manabu Honda
    • 1
  • Nobukatsu Sawamoto
    • 1
  • Shogo Yazawa
    • 1
  • Takeharu Kunieda
    • 4
  • Shinji Ohara
    • 1
  • Waro Taki
    • 4
  • Nobuo Hashimoto
    • 4
  • Yoshiharu Yonekura
    • 3
  • Junji Konishi
    • 2
  • Hiroshi Shibasaki
    • 1
  1. 1.Department of Brain Pathophysiology, Human Brain Reserch Center, Kyoto University Graduate School of Medince, Kyoto 606-8507, Japan
  2. 2.Department of Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
  3. 3.Biomedical Imaging Research Center, Fukui Medical University, Fukui 910–1193, Japan
  4. 4.Department of Neurosurgery, Kyoto Univseristy Graduate School of Medicine, Kyoto 606-8507, Japan
  5. 5.Human Motor Control Section, NINDS, NIH, Bethesda, MD 20892, USA
  6. 6.Laboratory of Cerebral Integration, National Institute for Physiological Scirences, Okazaki 444-8585, Japan