Experimental Brain Research

, Volume 129, Issue 4, pp 511–517

The role of the pedunculopontine region in basal-ganglia mechanisms of akinesia

  • L. E. Munro-Davies
  • J. Winter
  • T. Z. Aziz
  • J. F. Stein
Research Article

DOI: 10.1007/s002210050921

Cite this article as:
Munro-Davies, L., Winter, J., Aziz, T. et al. Exp Brain Res (1999) 129: 511. doi:10.1007/s002210050921

Abstract 

The akinesia of Parkinsonism is relieved by pallidotomy and subthalamic nucleotomy, but not by thalamotomy. Therefore, this disabling symptom probably depends upon connections other than the pallidal-thalamocortical tracts, possibly efferents of the medial pallidum descending to the upper brainstem. We have previously demonstrated akinesia in the normal monkey following radiofrequency lesioning in the region of the pedunculopontine nucleus (PPN), one of the primary targets for descending pallidal outflow. Here, we confirm that selectively destroying neurones in the PPN area, whilst sparing fibres of passage, results in an akinetic state in normal macaques.

Key words Parkinson’s Disease (PD)Pedunculopontine nucleus (PPN)AkinesiaKainic acid (KA)

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • L. E. Munro-Davies
    • 1
  • J. Winter
    • 1
  • T. Z. Aziz
    • 2
  • J. F. Stein
    • 1
  1. 1.Oxford University Laboratory of Physiology, Parks Road, Oxford 0X1 3PT, UKGB
  2. 2.Oxford University Department of Neurosurgery, Radcliffe Infirmary, Woodstock Road, Oxford 0X2 6HE, UKGB