Experimental Brain Research

, Volume 128, Issue 1, pp 181–187

Largely segregated parietofrontal connections linking rostral intraparietal cortex (areas AIP and VIP) and the ventral premotor cortex (areas F5 and F4)

  • G. Luppino
  • Akira Murata
  • Paolo Govoni
  • Massimo Matelli
Research Note

DOI: 10.1007/s002210050833

Cite this article as:
Luppino, G., Murata, A., Govoni, P. et al. Exp Brain Res (1999) 128: 181. doi:10.1007/s002210050833

Abstract 

Two functionally different cortical areas are located in the rostral part of the intraparietal sulcus (IP): the ventral intraparietal area (VIP), along the fundus of the sulcus, and the anterior intraparietal area (AIP), rostral in the lateral bank. VIP and AIP have functional properties comparable to those of the ventral premotor areas, F4 and F5, respectively. The aim of this study was to establish whether these intraparietal and premotor areas have direct and specific anatomical connections. Neural tracers were injected in F4, F5, and AIP in three macaque monkeys. The results showed that F4 and F5 are targets of strong projections from VIP and AIP, respectively, and that the linkage between F5 and AIP is highly selective. These data support the notion that parietofrontal connections selectively link areas displaying similar functional properties and form largely segregated anatomical circuits. Each of these circuits is possibly dedicated to specific aspects of sensorimotor transformations. In particular, the AIP-F5 circuit should play a crucial role in visuomotor transformation for grasping, the VIP-F4 circuit is possibly involved in peripersonal space coding for movement.

Key words Anatomical connections Primates Visuomotor transformations LIP 

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • G. Luppino
    • 1
  • Akira Murata
    • 2
  • Paolo Govoni
    • 3
  • Massimo Matelli
    • 1
  1. 1.Istituto di Fisiologia Umana, Università di Parma, Via Volturno 39, I-43100 Parma, Italy, e-mail: luppino@ipruniv.cce.unipr.it, Tel.: +39-521-903879, Fax: +39-521-903900IT
  2. 2.Department of Physiology, Nihon University, Oyaguchi-kaminachi 30-1, Itabashi-ku, 173-8610, Tokyo, JapanJP
  3. 3.Istituto di Istologia ed Embriologia, Università di Parma, Via Volturno 39, I-43100 Parma, ItalyIT