Experimental Brain Research

, Volume 135, Issue 3, pp 373–381

Retinogeniculate projections following early cerebral hemispherectomy in the vervet monkey

  • D. Boire
  • H. Théoret
  • M. Herbin
  • C. Casanova
  • M. Ptito
Research Article

DOI: 10.1007/s002210000527

Cite this article as:
Boire, D., Théoret, H., Herbin, M. et al. Exp Brain Res (2000) 135: 373. doi:10.1007/s002210000527

Abstract.

The effects of early, unilateral cerebral hemispherectomy on retinogeniculate projections were studied in the vervet monkey (Cercopithecus aethiops sabeus).Hemispherectomy eliminates all geniculocortical pathways and thus removes cortical factors involved in the survival of retinogeniculate projections. Complete removal of the left cerebral cortex was performed in two monkeys at 6 months and 8 months of age. After a postsurgical survival period of 50 months (SHG3) and 45 months (SHG4), both animals and a normal adult monkey received intraocular injections of [3H]proline (5 mCi) in the left eye and WGA-HRP (100 µl, 5%) in the right eye. The dorsal lateral geniculate nucleuseuron (LGNd) ipsilateral to the hemispherectomy was on average 73% smaller than the contralateral LGNd. The magno- and parvocellular layers ipsilateral to the cortical ablation in both hemispherectomized subjects received a layered, eye-specific pattern of retinal input. This suggests that retinogeniculate projections could be sustained in the absence of geniculate relay cells.

Visual cortex lesion Residual neurons Primate Cell death Retina Monkey

Copyright information

© Springer-Verlag 2000

Authors and Affiliations

  • D. Boire
    • 1
  • H. Théoret
    • 2
  • M. Herbin
    • 1
  • C. Casanova
    • 1
  • M. Ptito
    • 1
  1. 1.Ecole d'optométrie, Université de Montréal, CP 6128, succ. Centre-Ville, Montréal, Québec, Canada H3C 3J7
  2. 2.Groupe de Recherche en Neuropsychologie Expérimentale and Centre de Recherches en Sciences Neurologiques, Université de Montréal, CP 6128, Montréal, PQ, Canada H3C 3J7