Experimental Brain Research

, Volume 212, Issue 3, pp 371–384

Deficits in inhibitory control and conflict resolution on cognitive and motor tasks in Parkinson’s disease

Authors

  • Ignacio Obeso
    • Cognitive-Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement DisordersUCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery
  • Leonora Wilkinson
    • Cognitive-Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement DisordersUCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery
    • Brain Stimulation UnitNational Institute of Neurological Disorders and Stroke
  • Enrique Casabona
    • Movement Disorders and Neurophysiology UnitsCentro Internacional de Restauración Neurológica (CIREN)
  • Maria Luisa Bringas
    • Movement Disorders and Neurophysiology UnitsCentro Internacional de Restauración Neurológica (CIREN)
  • Mario Álvarez
    • Movement Disorders and Neurophysiology UnitsCentro Internacional de Restauración Neurológica (CIREN)
  • Lázaro Álvarez
    • Movement Disorders and Neurophysiology UnitsCentro Internacional de Restauración Neurológica (CIREN)
  • Nancy Pavón
    • Movement Disorders and Neurophysiology UnitsCentro Internacional de Restauración Neurológica (CIREN)
  • Maria-Cruz Rodríguez-Oroz
    • Department of Neurology, Clínica Universitaria and Medical School of Navarra, Neuroscience Centre, CIMAUniversity of Navarra
    • Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto Carlos IIIMinisterio de Investigación y Ciencias
  • Raúl Macías
    • Movement Disorders and Neurophysiology UnitsCentro Internacional de Restauración Neurológica (CIREN)
  • Jose A. Obeso
    • Department of Neurology, Clínica Universitaria and Medical School of Navarra, Neuroscience Centre, CIMAUniversity of Navarra
    • Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto Carlos IIIMinisterio de Investigación y Ciencias
    • Cognitive-Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement DisordersUCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery
Research Article

DOI: 10.1007/s00221-011-2736-6

Cite this article as:
Obeso, I., Wilkinson, L., Casabona, E. et al. Exp Brain Res (2011) 212: 371. doi:10.1007/s00221-011-2736-6

Abstract

Recent imaging studies in healthy controls with a conditional stop signal reaction time (RT) task have implicated the subthalamic nucleus (STN) in response inhibition and the pre-supplementary motor area (pre-SMA) in conflict resolution. Parkinson’s disease (PD) is characterized by striatal dopamine deficiency and overactivity of the STN and underactivation of the pre-SMA during movement. We used the conditional stop signal RT task to investigate whether PD produced similar or dissociable effects on response initiation, response inhibition and response initiation under conflict. In addition, we also examined inhibition of prepotent responses on three cognitive tasks: the Stroop, random number generation and Hayling sentence completion. PD patients were impaired on the conditional stop signal reaction time task, with response initiation both in situations with or without conflict and response inhibition all being significantly delayed, and had significantly greater difficulty in suppressing prepotent or habitual responses on the Stroop, Hayling and random number generation tasks relative to controls. These results demonstrate the existence of a generalized inhibitory deficit in PD, which suggest that PD is a disorder of inhibition as well as activation and that in situations of conflict, executive control over responses is compromised.

Keywords

Fronto-striatal circuitsParkinson’s diseaseSubthalamic nucleusInhibitionStop signal task

Copyright information

© Springer-Verlag 2011