Experimental Brain Research

, Volume 187, Issue 1, pp 25–31

Impairment of movement-associated brain deactivation in multiple sclerosis: further evidence for a functional pathology of interhemispheric neuronal inhibition

Authors

  • S. C. Manson
    • Centre for Functional Magnetic Resonance Imaging of the BrainUniversity of Oxford
    • Experimental RadiologyNational Institutes of Health
  • C. Wegner
    • Centre for Functional Magnetic Resonance Imaging of the BrainUniversity of Oxford
  • M. Filippi
    • Neuroimaging Research Unit, Department of NeurologyScientific Institute and University
  • F. Barkhof
    • Department of RadiologyVU University Medical Centre
  • C. Beckmann
    • Centre for Functional Magnetic Resonance Imaging of the BrainUniversity of Oxford
  • O. Ciccarelli
    • NMR Research Unit, Institute of NeurologyUniversity College London
  • N. De Stefano
    • Department of Neurological and Behavioural SciencesUniversity of Siena
  • Christian Enzinger
    • Department of NeurologyMedical University Graz
  • F. Fazekas
    • Department of NeurologyMedical University Graz
  • F. Agosta
    • Neuroimaging Research Unit, Department of NeurologyScientific Institute and University
  • A. Gass
    • Department of NeurologyUniversity Hospital
  • J. Hirsch
    • Department of NeurologyUniversity Hospital
  • H. Johansen-Berg
    • Centre for Functional Magnetic Resonance Imaging of the BrainUniversity of Oxford
  • L. Kappos
    • Department of NeurologyUniversity Hospital
  • T. Korteweg
    • Department of RadiologyVU University Medical Centre
  • C. Polman
    • Department of RadiologyVU University Medical Centre
  • L. Mancini
    • NMR Research Unit, Institute of NeurologyUniversity College London
    • Department of Neuroradiology, National Hospital for Neurology and NeurosurgeryUCLH NHS Foundation Trust
  • F. Manfredonia
    • NMR Research Unit, Institute of NeurologyUniversity College London
  • S. Marino
    • Department of Neurological and Behavioural SciencesUniversity of Siena
  • D. H. Miller
    • NMR Research Unit, Institute of NeurologyUniversity College London
  • X. Montalban
    • Department of Radiology, Magnetic Resonance UnitHospital Vall d’Hebron
  • J. Palace
    • Centre for Functional Magnetic Resonance Imaging of the BrainUniversity of Oxford
  • M. Rocca
    • Neuroimaging Research Unit, Department of NeurologyScientific Institute and University
  • S. Ropele
    • Department of NeurologyMedical University Graz
  • A. Rovira
    • Department of Radiology, Magnetic Resonance UnitHospital Vall d’Hebron
  • S. Smith
    • Centre for Functional Magnetic Resonance Imaging of the BrainUniversity of Oxford
  • A. Thompson
    • NMR Research Unit, Institute of NeurologyUniversity College London
  • J. Thornton
    • NMR Research Unit, Institute of NeurologyUniversity College London
  • T. Yousry
    • NMR Research Unit, Institute of NeurologyUniversity College London
  • J. A. Frank
    • Experimental RadiologyNational Institutes of Health
    • Centre for Functional Magnetic Resonance Imaging of the BrainUniversity of Oxford
    • Department of Clinical NeurosciencesImperial College
    • Clinical Imaging Centre, Clinical Pharmacology and Discovery MedicineGlaxoSmithKline, Hammersmith Hospital
Research Article

DOI: 10.1007/s00221-008-1276-1

Cite this article as:
Manson, S.C., Wegner, C., Filippi, M. et al. Exp Brain Res (2008) 187: 25. doi:10.1007/s00221-008-1276-1

Abstract

Motor control demands coordinated excitation and inhibition across distributed brain neuronal networks. Recent work has suggested that multiple sclerosis (MS) may be associated with impairments of neuronal inhibition as part of more general progressive impairments of connectivity. Here, we report results from a prospective, multi-centre fMRI study designed to characterise the changes in patients relative to healthy controls during a simple cued hand movement task. This study was conducted at eight European sites using 1.5 Tesla scanners. Brain deactivation during right hand movement was assessed in 56 right-handed patients with relapsing-remitting or secondary progressive MS without clinically evident hand impairment and in 60 age-matched, healthy subjects. The MS patients showed reduced task-associated deactivation relative to healthy controls in the pre- and postcentral gyri of the ipsilateral hemisphere in the region functionally specialised for hand movement control. We hypothesise that this impairment of deactivation is related to deficits of transcallosal connectivity and GABAergic neurotransmission occurring with the progression of pathology in the MS patients. This study has substantially extended previous observations with a well-powered, multicentre study. The clinical significance of these deactivation changes is still uncertain, but the functional anatomy of the affected region suggests that they could contribute to impairments of motor control.

Keywords

fMRIMultiple sclerosisMovementInhibitory neurotransmission

Abbreviations

EDSS

Extended Disability Status Score

EPI

Echoplanar image

fMRI

Functional MRI

MNI

Montreal Neurological Institute

PMd

Dorsal premotor cortex

ROI

Region of interest

Copyright information

© Springer-Verlag 2008