Experimental Brain Research

, Volume 170, Issue 2, pp 206–215

Evolution of postural stability after subthalamic nucleus stimulation in Parkinson’s disease: a combined clinical and posturometric study

  • D. Guehl
  • P. Dehail
  • M.P. de Sèze
  • E. Cuny
  • P. Faux
  • F. Tison
  • M. Barat
  • B. Bioulac
  • P. Burbaud
Research Article

DOI: 10.1007/s00221-005-0202-z

Cite this article as:
Guehl, D., Dehail, P., de Sèze, M. et al. Exp Brain Res (2006) 170: 206. doi:10.1007/s00221-005-0202-z

Abstract

Objectives: The occurrence of postural and balance disorders is a frequent feature in advanced forms of Parkinson’s disease (PD). However, the pathological substrate of these disturbances is poorly understood. Methods: In the present work, we investigated the evolution of posturometric parameters [center of pressure (CoP) displacement and CoP area] and axial scores between the pre-operative period and 3 months post-operative in seven PD patients who underwent bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN). Results: After surgery, the patients leaned backwards much more regardless of the STN stimulation, suggesting that surgery could have a deleterious effect on postural adaptation. During the post-operative period, the improvement in axial and postural scores was similar under levodopatherapy and DBS. On the other hand, DBS of the STN significantly reduced the CoP displacement and the CoP area, whereas levodopatherapy tended only to reduce the CoP displacement and to increase the CoP area significantly. Conclusions: These data suggest that DBS of the STN and levodopa do not act on the same neurological systems involved in posture regulation. DBS of the STN could improve posture via a direct effect on the pedunculopontine nucleus, which is known to be involved in posture regulation.

Keywords

Parkinson’s disease Subthalamic nucleus DBS Posturometry 

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • D. Guehl
    • 1
  • P. Dehail
    • 2
  • M.P. de Sèze
    • 2
  • E. Cuny
    • 3
  • P. Faux
    • 2
  • F. Tison
    • 4
  • M. Barat
    • 2
  • B. Bioulac
    • 1
  • P. Burbaud
    • 1
  1. 1.Service de Neurophysiologie Clinique, Hôpital Pellegrin, Place Amélie-Raba-LéonCNRS UMR 5543, Université de BordeauxBordeauxFrance
  2. 2.Service de Médecine physique et réadaptation, Hôpital Pellegrin, Place Amélie-Raba-LéonCNRS UMR 5543, Université de BordeauxBordeauxFrance
  3. 3.Service de Neurochirurgie, Hôpital Pellegrin, Hôpital Pellegrin, Place Amélie-Raba-LéonCNRS UMR 5543, Université de BordeauxBordeauxFrance
  4. 4.Service de Neurologie, Hôpital Hauī Lēvĉque, PessacCNRS UMR 5543, Université de BordeauxBordeauxFrance