Experimental Brain Research

, Volume 160, Issue 4, pp 517–527

Effects of bilateral subthalamic stimulation on gait kinematics and kinetics in Parkinson’s disease

  • M. Ferrarin
  • M. Rizzone
  • B. Bergamasco
  • M. Lanotte
  • M. Recalcati
  • A. Pedotti
  • L. Lopiano
Research Article

DOI: 10.1007/s00221-004-2036-5

Cite this article as:
Ferrarin, M., Rizzone, M., Bergamasco, B. et al. Exp Brain Res (2005) 160: 517. doi:10.1007/s00221-004-2036-5

Abstract.

Subthalamic nucleus (STN) stimulation, a recent surgical approach to Parkinson’s disease (PD), has been shown to be effective in relieving motor symptoms. The present study carried out a full body gait analysis, during overground walking, on ten PD patients with bilaterally implanted STN stimulation devices. Walking performance was analyzed on the same day, in four conditions (Stim Off–Med Off, Stim On–Med Off, Stim Off–Med On, Stim On–Med On). The results showed that, on average, STN stimulation alone (S+M−) and l -dopa alone (S-M+), significantly increased gait speed, stride length and the lower limb joint Range of Motion (ROM) with respect to the basal condition (S−M−); also cadence was found to play a role in velocity increase, particularly when l -dopa was administered. Both treatments improved pelvis and trunk kinematics, and power production at the ankle and hip joints. The combination of the two treatments (S+M+) produced an additional effect on gait speed, stride length, ROM of knee and ankle joints, pelvis obliquity and trunk inclination. Given the additive and synergistic effects, it can be hypothesized that the two treatments have different mechanisms of action. Our results confirm the findings of earlier studies that employed treadmill walking.

Keywords

Gait analysisParkinson’s diseaseSubthalamic nucleus stimulationDeep brain stimulationMotor rehabilitation

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • M. Ferrarin
    • 1
    • 7
  • M. Rizzone
    • 2
    • 3
  • B. Bergamasco
    • 2
    • 4
  • M. Lanotte
    • 5
  • M. Recalcati
    • 1
  • A. Pedotti
    • 6
  • L. Lopiano
    • 2
  1. 1.Centro di Bioingegneria FDGFond. Don Carlo Gnocchi ONLUS IRCCSMilanItaly
  2. 2.Dipartimento di NeuroscienzeUniversità di TorinoTurinItaly
  3. 3.Dipartimento di NeuroscienzeOspedale Niguarda Cà GrandaMilanItaly
  4. 4.Fondazione Salvatore MaugeriPaviaItaly
  5. 5.Divisione di NeurochirurgiaOspedale CTOTurinItaly
  6. 6.Dipartimento di BioingegneriaPolitecnico di MilanoMilanItaly
  7. 7.Centro di Bioingegneria FDGFondazione Don Carlo Gnocchi IRCCSMilanItaly