Experimental Brain Research

, Volume 156, Issue 4, pp 513–517

Attention to pain is processed at multiple cortical sites in man

  • Shinji Ohara
  • Nathan E. Crone
  • Nirit Weiss
  • Hagen Vogel
  • Rolf-Detlef Treede
  • Fred A. Lenz
Research Note

DOI: 10.1007/s00221-004-1885-2

Cite this article as:
Ohara, S., Crone, N.E., Weiss, N. et al. Exp Brain Res (2004) 156: 513. doi:10.1007/s00221-004-1885-2

Abstract

Painful cutaneous laser stimuli evoked potentials (LEPs) were recorded over the primary somatosensory (SI), parasylvian, and medial frontal (MF) cortex areas in a patient with subdural electrode grids located over these areas for surgical treatment of epilepsy. The amplitudes of the negative (N2*) and positive (P2**) LEP peaks over SI, parasylvian, and MF cortex were enhanced by attention to (counting stimuli), in comparison with distraction from the stimulus (reading for comprehension). Late positive deflections following the P2** peak (late potential—LP) were recorded over MF and from the lateral premotor regions during attention but not during distraction. These findings suggest that attention gates both early (N2*) and late (P2**) pain-related input to SI, parasylvian, and MF cortical regions while the later components (LP) are specifically related to attention.

Keywords

Attention to painDistributed cortical networkLaser evoked potentialsEpilepsySubdural electrode gridsSomatosensory cortex

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Shinji Ohara
    • 1
  • Nathan E. Crone
    • 2
  • Nirit Weiss
    • 1
  • Hagen Vogel
    • 3
  • Rolf-Detlef Treede
    • 3
  • Fred A. Lenz
    • 1
    • 4
  1. 1.Department of NeurosurgeryJohns Hopkins HospitalBaltimoreUSA
  2. 2.Department of NeurologyJohns Hopkins HospitalBaltimoreUSA
  3. 3.Institute of Physiology and PathophysiologyJohannes Gutenberg UniversityMainzGermany
  4. 4.Department of NeurosurgeryJohns Hopkins HospitalBaltimoreUSA