Analytical and Bioanalytical Chemistry

, Volume 404, Issue 4, pp 1181–1196

Affinity and enzyme-based biosensors: recent advances and emerging applications in cell analysis and point-of-care testing

Authors

  • Ying Liu
    • Department of Biomedical EngineeringUniversity of California
  • Zimple Matharu
    • Department of Biomedical EngineeringUniversity of California
  • Michael C. Howland
    • Department of Biomedical EngineeringUniversity of California
    • Department of Biomedical EngineeringUniversity of California
    • Department of Materials EngineeringAuburn University
Review

DOI: 10.1007/s00216-012-6149-6

Cite this article as:
Liu, Y., Matharu, Z., Howland, M.C. et al. Anal Bioanal Chem (2012) 404: 1181. doi:10.1007/s00216-012-6149-6

Abstract

The applications of biosensors range from environmental testing and biowarfare agent detection to clinical testing and cell analysis. In recent years, biosensors have become increasingly prevalent in clinical testing and point-of-care testing. This is driven in part by the desire to decrease the cost of health care, to shift some of the analytical tests from centralized facilities to “frontline” physicians and nurses, and to obtain more precise information more quickly about the health status of a patient. This article gives an overview of recent advances in the field of biosensors, focusing on biosensors based on enzymes, aptamers, antibodies, and phages. In addition, this article attempts to describe efforts to apply these biosensors to clinical testing and cell analysis.

https://static-content.springer.com/image/art%3A10.1007%2Fs00216-012-6149-6/MediaObjects/216_2012_6149_Figa_HTML.gif
Figure

Biosensor for Point of care

Keywords

BiosensorEnzymeAptamersPhagePoint of care

Copyright information

© Springer-Verlag 2012