, Volume 402, Issue 6, pp 1993-2013
Date: 17 Jan 2012

Comprehensive two-dimensional gas chromatography in metabolomics

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One of the major objectives in metabolomics is the identification of subtle changes in metabolite profiles as affected by genetic or environmental factors. Comprehensive two-dimensional gas chromatography (GC × GC) hyphenated to a fast-acquisition mass spectrometer is a well-established analytical technique to study the composition of complex samples due to its enhanced separation capacity, sensitivity, peak resolution, and reproducibility. This review reports applications of GC × GC to metabolomics studies of sample of different types (biofluid, cells, tissue, bacteria, yeast, plants), and discusses its advantages and limitations.

Published in the special issue Comprehensive Multidimensional Separations with guest editors James Harynuk and Philip Marriott.