Analytical and Bioanalytical Chemistry

, Volume 399, Issue 10, pp 3307–3322

Development of silica-based stationary phases for high-performance liquid chromatography

  • Hongdeng Qiu
  • Xiaojing Liang
  • Min Sun
  • Shengxiang Jiang
Review

DOI: 10.1007/s00216-010-4611-x

Cite this article as:
Qiu, H., Liang, X., Sun, M. et al. Anal Bioanal Chem (2011) 399: 3307. doi:10.1007/s00216-010-4611-x

Abstract

Stationary phases are the basis of the development and application of high-performance liquid chromatography (HPLC). In this review we focused on the development of silica-based stationary phases, including the synthesis of silica gel and the application of silica in hydrophilic interaction chromatography (HILIC), reversed-phase liquid chromatography (RPLC), chiral separation chromatography, and ion chromatography. New stationary phases, advances in ionic liquid-modified silica, silica-based core-shell materials, and silica-based monolithic columns for HPLC are introduced separately.

Keywords

High-performance liquid chromatography Silica stationary phase Ionic liquid-modified silica Organic–inorganic modification Chiral separation 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Hongdeng Qiu
    • 1
  • Xiaojing Liang
    • 1
  • Min Sun
    • 1
    • 2
  • Shengxiang Jiang
    • 1
  1. 1.Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhouChina
  2. 2.Graduate School of the Chinese Academy of SciencesChinese Academy of SciencesBeijingChina

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