Review

Analytical and Bioanalytical Chemistry

, Volume 398, Issue 6, pp 2535-2549

Sizing up the future of microRNA analysis

  • Abraham J. QaviAffiliated withDepartment of Chemistry, Institute for Genomic Biology, and Micro and Nanotechnology Laboratory, University of Illinois
  • , Jared T. KindtAffiliated withDepartment of Chemistry, Institute for Genomic Biology, and Micro and Nanotechnology Laboratory, University of Illinois
  • , Ryan C. BaileyAffiliated withDepartment of Chemistry, Institute for Genomic Biology, and Micro and Nanotechnology Laboratory, University of Illinois Email author 

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Abstract

In less than 20 years, our appreciation for micro-RNA molecules (miRNAs) has grown from an original, curious observation in worms to their current status as incredibly important global regulators of gene expression that play key roles in many transformative biological processes. As our understanding of these small, non-coding transcripts continues to evolve, new approaches for their analysis are emerging. In this critical review we describe recent improvements to classical methods of detection as well as innovative new technologies that are poised to help shape the future landscape of miRNA analysis.

http://static-content.springer.com/image/art%3A10.1007%2Fs00216-010-4018-8/MediaObjects/216_2010_4018_Figa_HTML.gif
Figure

Driven by the ever increasing appreciation of the critical biological roles played by microRNAs, new technologies are continually reshaping the landscape of microRNA analysis. This review highlights existing and emerging technologies for the detection of microRNAs

Keywords

Bioanalytical methods Bioassays Biosensors Nucleic acids (DNA | RNA)