Trends

Analytical and Bioanalytical Chemistry

, Volume 397, Issue 3, pp 909-916

First online:

Microdialysis-based sensing in clinical applications

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Abstract

The need for fast and continuous measurements in the biomedical field is driving scientists to look for an alternative to blood sampling. This implies the adoption of invasive approaches, which, in some cases, may lead to reduced safety for the patient; consequently this strategy is pursued only if it is unavoidable. Microdialysis-based sensing provides a minimally invasive solution, with biological samples drawn by means of a microdialysis catheter and examined outside the human body. Therefore, it has become a promising approach to investigate the interstitial fluid in human brain and subcutaneous adipose tissue, providing important information on the tissue biochemistry and metabolism. Advantages and limitations of microdialysis are considered here and the applications in the clinical field are described, with the provision of some examples and with a view to the new perspectives in the field.

https://static-content.springer.com/image/art%3A10.1007%2Fs00216-010-3626-7/MediaObjects/216_2010_3626_Figa_HTML.gif
Figure

Microdialysis probe inserted in the tissue. Black arrows indicate the diffusion of the analyte through the dialysis membrane and red arrows indicate the flow of the solution inside the probe

Keywords

Microdialysis Point-of-care testing Home care Adipose tissue