Analytical and Bioanalytical Chemistry

, Volume 396, Issue 3, pp 1311–1320

Development of liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry for analysis of halogenated flame retardants in wastewater

Authors

    • Department of ChemistryBrock University
    • Ontario Ministry of the EnvironmentLaboratory Services Branch
  • Eric J. Reiner
    • Ontario Ministry of the EnvironmentLaboratory Services Branch
  • Chris Marvin
    • Environment CanadaNational Water Research Institute
  • Paul Helm
    • Ontario Ministry of the EnvironmentEnvironmental Monitoring and Reporting Branch
  • Nicole Riddell
    • Wellington Laboratories
  • Frank Dorman
    • Restek Corporation
    • Juniata College Department of Chemistry
  • Michelle Misselwitz
    • Restek Corporation
  • Li Shen
    • Department of ChemistryBrock University
    • Ontario Ministry of the EnvironmentLaboratory Services Branch
  • Patrick Crozier
    • Ontario Ministry of the EnvironmentLaboratory Services Branch
  • Karen MacPherson
    • Ontario Ministry of the EnvironmentLaboratory Services Branch
  • Ian D. Brindle
    • Department of ChemistryBrock University
Original Paper

DOI: 10.1007/s00216-009-3279-6

Cite this article as:
Zhou, S.N., Reiner, E.J., Marvin, C. et al. Anal Bioanal Chem (2010) 396: 1311. doi:10.1007/s00216-009-3279-6

Abstract

Until recently, atmospheric pressure photoionization (APPI) has typically been used for the determination of non-polar halogenated flame retardants (HFRs) by liquid chromatography (LC) tandem mass spectrometry. In this study, we demonstrated the feasibility of utilizing liquid chromatography atmospheric pressure chemical ionization (APCI) tandem mass spectrometry (LC-APCI-MS/MS) for analysis of 38 HFRs. This developed method offered three advantages: simplicity, rapidity, and high sensitivity. Compared with APPI, APCI does not require a UV lamp and a dopant reagent to assist atmospheric pressure ionization. All the isomers and the isobaric compounds were well resolved within 14-min LC separation time. Excellent instrument detection limits (6.1 pg on average with 2.0 μL injection) were observed. The APCI mechanism was also investigated. The method developed has been applied to the screening of wastewater samples for screening purpose, with concentrations determined by LC-APCI-MS/MS agreeing with data obtained via gas chromatography high resolution mass spectrometry.

https://static-content.springer.com/image/art%3A10.1007%2Fs00216-009-3279-6/MediaObjects/216_2009_3279_Figa_HTML.gif
Figure

LC-APCI-MS/MS for analysis of halogenated flame reterdants

Keywords

Atmospheric pressure chemical ionization (APCI)Liquid chromatography tandem mass spectrometry (LC-MS/MS)Halogenated flame retardants (HFRs)Wastewater

Copyright information

© Springer-Verlag 2009