Development of tip-enhanced optical spectroscopy for biological applications: a review
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- Elfick, A.P.D., Downes, A.R. & Mouras, R. Anal Bioanal Chem (2010) 396: 45. doi:10.1007/s00216-009-3223-9
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Tip-enhanced optical spectroscopy is an approach that holds a good deal of promise for the nanoscale characterisation of matter. Tip-enhanced Raman spectroscopy (TERS) has been demonstrated on a variety of samples: inorganic, organic and biological. Imaging using TERS has been shown for carbon nanotubes due to their high scattering efficiency. There are a number of compelling motivations to consider alternative approaches for biological samples; most importantly, the potential for heat damage of biomolecules and long acquisition times. These issues may be addressed through the development of tip-enhanced coherent anti-Stokes Raman scattering microscopy.