, Volume 395, Issue 4, pp 877-891
Date: 28 Jul 2009

Antibiotics in food: Legislation and validation of analytical methodologies

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In this paper, European food safety legislation is presented, and special attention is devoted to monitoring residues of veterinary drugs in foodstuffs of animal origin. After a short review of the state of the art of analytical methodology for antibiotic residue analysis, the paper focuses on validation of analytical methods, with Decision 657/2002/EC as reference document. Finally, the main issues of the quality control of the analytical data, i.e. analysis of reference materials and participation in proficiency tests, are briefly addressed.

An erratum to this article can be found at http://dx.doi.org/10.1007/s00216-009-3213-y