Analytical and Bioanalytical Chemistry

, Volume 391, Issue 7, pp 2469–2495

Semiconductor quantum dots and metal nanoparticles: syntheses, optical properties, and biological applications

  • Vasudevanpillai Biju
  • Tamitake Itoh
  • Abdulaziz Anas
  • Athiyanathil Sujith
  • Mitsuru Ishikawa
Review

DOI: 10.1007/s00216-008-2185-7

Cite this article as:
Biju, V., Itoh, T., Anas, A. et al. Anal Bioanal Chem (2008) 391: 2469. doi:10.1007/s00216-008-2185-7

Abstract

We review the syntheses, optical properties, and biological applications of cadmium selenide (CdSe) and cadmium selenide–zinc sulfide (CdSe–ZnS) quantum dots (QDs) and gold (Au) and silver (Ag) nanoparticles (NPs). Specifically, we selected the syntheses of QDs and Au and Ag NPs in aqueous and organic phases, size- and shape-dependent photoluminescence (PL) of QDs and plasmon of metal NPs, and their bioimaging applications. The PL properties of QDs are discussed with reference to their band gap structure and various electronic transitions, relations of PL and photoactivated PL with surface defects, and blinking of single QDs. Optical properties of Ag and Au NPs are discussed with reference to their size- and shape-dependent surface plasmon bands, electron dynamics and relaxation, and surface-enhanced Raman scattering (SERS). The bioimaging applications are discussed with reference to in vitro and in vivo imaging of live cells, and in vivo imaging of cancers, tumor vasculature, and lymph nodes. Other aspects of the review are in vivo deep tissue imaging, multiphoton excitation, NIR fluorescence and SERS imaging, and toxic effects of NPs and their clearance from the body.

Figure

Semiconductor quantum dots and metal nanoparticles have extensive applications, e.g., in vitro and in vivo bioimaging

Keywords

Quantum dots CdSe CdSe–ZnS Photoluminescence Blinking Nanoparticles Au Ag Plasmon SERS In vitro imaging In vivo imaging 

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Vasudevanpillai Biju
    • 1
    • 2
  • Tamitake Itoh
    • 1
  • Abdulaziz Anas
    • 1
  • Athiyanathil Sujith
    • 1
  • Mitsuru Ishikawa
    • 1
    • 2
  1. 1.Nano-Bioanalysis Team, Health Technology Research CenterNational Institute of Advanced Industrial Science and Technology (AIST)TakamatsuJapan
  2. 2.Center for Arthropod Bioresources and BiotechnologyKerala UniversityTrivandrumIndia

Personalised recommendations