Analytical and Bioanalytical Chemistry

, Volume 390, Issue 1, pp 89–111

Polymer microfabrication technologies for microfluidic systems

Review

DOI: 10.1007/s00216-007-1692-2

Cite this article as:
Becker, H. & Gärtner, C. Anal Bioanal Chem (2008) 390: 89. doi:10.1007/s00216-007-1692-2

Abstract

Polymers have assumed the leading role as substrate materials for microfluidic devices in recent years. They offer a broad range of material parameters as well as material and surface chemical properties which enable microscopic design features that cannot be realised by any other class of materials. A similar range of fabrication technologies exist to generate microfluidic devices from these materials. This review will introduce the currently relevant microfabrication technologies such as replication methods like hot embossing, injection molding, microthermoforming and casting as well as photodefining methods like lithography and laser ablation for microfluidic systems and discuss academic and industrial considerations for their use. A section on back-end processing completes the overview.

Keywords

MicrofluidicsMicrofabricationPolymersBiochipsHigh throughput screeningMiniaturization

Abbreviations

CE

Capillary electrophoresis

COC/COP

Cycloolefin/copolymer

DT

Decomposition temperature

HDT

Heat distortion temperature

LIGA

Lithographie (lithography), galvanoformung (electroplating), abformung (molding)

MEMS

Micro electromechanical systems

μ-TAS

Miniaturized total analysis system

μ-EDM

Micro-electrode discharge machining

MST

Microsystem technology

TAS

Total analysis system

Tg

Glass transition temperature

PC

Polycarbonate

PDMS

Poly(dimethylsiloxane)

PE

Polyethylene

PEEK

Polyetheretherketone

PFPE

Perfluoropolyether

PI

Polyimide

PMMA

Poly(methyl methacrylate)

POC

Point-of-care

PP

Polypropylene

PS

Polystyrene

TPE

Thermoset polyester

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.microfluidic ChipShop GmbHJenaGermany