Analytical and Bioanalytical Chemistry

, Volume 386, Issue 7, pp 2087–2094

Selective detection of dopamine in the presence of ascorbic acid by use of glassy-carbon electrodes modified with both polyaniline film and multi-walled carbon nanotubes with incorporated β-cyclodextrin

Original Paper

DOI: 10.1007/s00216-006-0845-z

Cite this article as:
Yin, T., Wei, W. & Zeng, J. Anal Bioanal Chem (2006) 386: 2087. doi:10.1007/s00216-006-0845-z

Abstract

A simple, sensitive, and reliable method based on a combination of multi-walled carbon nanotubes with incorporated β-cyclodextrin (β-CD-MWNTs) and a polyaniline (PANI) film-modified glassy-carbon (GC) electrode has been successfully developed for determination of dopamine (DA) in the presence of ascorbic acid (AA). The PANI film had good anti-interference properties and long-term stability, because of the permselective and protective properties of the conducting redox polymer film. The acid-treated MWNTs with carboxylic acid functional groups promoted the electron-transfer reaction of DA and inhibited the voltammetric response of AA. Sensitive detection of DA was further improved by the preconcentration effect of formation of a supramolecular complex between β-CD and DA. The analytical response of the β-CD-MWNTs/PANI film to the electrochemical behavior of DA was, therefore, better than that of a MWNTs/PANI film, a PANI film, or a bare glassy-carbon (GC) electrode. Under the conditions chosen a linear calibration plot was obtained in the range 1.0 × 10−7–1.0 × 10−3 mol L−1 and the detection limit was 1.2 × 10−8 mol L−1. Interference from AA was effectively eliminated and the sensitivity, selectivity, stability, and reproducibility of the electrodes was excellent for determination of DA.

Keywords

Dopamineβ-CyclodextrinMulti-walled carbon nanotubesPolyaniline

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.State Key Laboratory of Chemical, Biological Sensing Technologies and ChemometricsHunan UniversityChangshaPeople’s Republic of China