Analytical and Bioanalytical Chemistry

, Volume 385, Issue 7, pp 1304–1323

Selenium speciation from food source to metabolites: a critical review

Review

DOI: 10.1007/s00216-006-0529-8

Cite this article as:
Dumont, E., Vanhaecke, F. & Cornelis, R. Anal Bioanal Chem (2006) 385: 1304. doi:10.1007/s00216-006-0529-8

Abstract

Especially in the last decade, a vast number of papers on Se and its role in health issues have been published. This review gives a brief, critical overview of the main analytical findings reported in these papers. Of particular interest is the Se content in different food sources worldwide and the extent to which their consumption is reflected in the Se content of human tissues and body fluids. Several food sources, both natural (Brazil nuts, garlic, Brassica juncea) and Se-enriched (yeast-based supplements), are discussed as to origin, characteristics, Se metabolism and impact of their consumption on the human body. The continuous development of new and improvement of existing analytical techniques has provided different powerful tools to unravel the Se species and their function. An up-to-date literature study on Se speciation analysis is given, illustrating how analytical chemistry in its different facets aids in the identification of Se compounds and provides insight into the complete metabolic pathway of Se throughout the human body. This review includes a detailed image of the current state-of-the-art of Se speciation analysis in these food sources and in human tissues and body fluids.

Keywords

SeleniumSpeciationAnalytical techniquesFoodMetabolites

Abbreviations

AED

Atomic Emission Detection

APCI

Atmospheric Pressure Chemical Ionization

2D-LC

Two-dimensional Liquid Chromatography

DMDSe

Dimethyldiselenide

DMSe

Dimethylselenide

DMSeP

Dimethylseleniopropionate

CE

Capillary Electrophoresis

ESI

Electrospray Ionization

GC

Gas Chromatography

γ–glu–Se–MeSeCys

γ–glutamine–Se–MethylselenoCysteine

ICP-MS

Inductively Coupled Plasma Mass Spectrometry

LA

Laser Ablation

LC

Liquid Chromatography

MALDI

Matrix Assisted Laser Desorption Ionization

MIP

Microwave Induced Plasma

MS

Mass Spectrometry

Q

Quadrupole

RDA

Recommended Dietary Allowance

RDI

Recommended Dietary Intake

RPLC

Reversed Phase Liquid Chromatography

SDS

Sodium Dodecyl Sulfate

SEC

Size Exclusion Chromatography

Se–Cya

Se–Cystamine

Se–Cys

Se–Cysteine

Se–(Cys)2

Se–Cystine

Se–MeSeCys

Se–MethylselenoCysteine

Se–MeSeMet

Se–MethylselenoMethionine

Se–Met

Se–Methionine

SPME

Solid Phase Micro Extraction

TMSe+

Trimethylselenonium ion

TOF

Time-of-Flight

UPLC

Ultra Pressure Liquid Chromatography

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Department of Analytical ChemistryGhent UniversityGhentBelgium