Analytical and Bioanalytical Chemistry

, Volume 382, Issue 3, pp 728–734

Retention characteristics of a new butylimidazolium-based stationary phase

  • Y. Sun
  • B. Cabovska
  • C. E. Evans
  • T. H. Ridgway
  • A. M. Stalcup
Original Paper

DOI: 10.1007/s00216-004-3051-x

Cite this article as:
Sun, Y., Cabovska, B., Evans, C.E. et al. Anal Bioanal Chem (2005) 382: 728. doi:10.1007/s00216-004-3051-x

Abstract

A new HPLC stationary phase has been synthesized based on the ionic liquid n-butylimidazolium bromide. Imidazolium was covalently immobilized on a silica substrate through an n-alkyl tether and the retention characteristics of the resulting stationary phase were evaluated systematically. Using 28 small aromatic test solutes and reversed phase conditions, the linear solvation energy relationship approach was successfully used to characterize this new phase. The retention characteristics of the test solutes show remarkable similarity with phenyl stationary phases, despite the presence of a positive charge on the new imidazolium phase. Operated in the reversed phase mode, this new stationary phase shows considerable promise for the separation of neutral solutes and points to the potential for a truly multi-modal stationary phase.

Keywords

Butylimidazolium bromide LSER Reversed phase HPLC Ionic liquids Retention mechanisms 

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Y. Sun
    • 3
  • B. Cabovska
    • 1
    • 3
  • C. E. Evans
    • 2
    • 3
  • T. H. Ridgway
    • 3
  • A. M. Stalcup
    • 3
  1. 1.PPRU-Laboratory of Applied Pharmacokinetics and Therapeutic Drug ManagementCincinnati Children’s Hospital Medical CenterCincinnatiUSA
  2. 2.Department of Chemistry, 215 UCBUniversity of ColoradoBoulderUSA
  3. 3.Department of ChemistryUniversity of CincinnatiCincinnatiUSA

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