Analytical and Bioanalytical Chemistry

, Volume 379, Issue 7, pp 920–930

A unified view of propagating and localized surface plasmon resonance biosensors


DOI: 10.1007/s00216-004-2708-9

Cite this article as:
Haes, A.J. & Van Duyne, R.P. Anal Bioanal Chem (2004) 379: 920. doi:10.1007/s00216-004-2708-9


The intense colors of noble metal nanoparticles have inspired artists and fascinated scientists for hundreds of years. In this review, we describe refractive index sensing platforms based on the tunability of the localized surface plasmon resonance (LSPR) of arrays of silver nanoparticles and of single nanoparticles. Specifically, the color associated with single nanoparticles and surface-confined nanoparticle arrays will be shown to be tunable and useful as platforms for chemical and biological sensing. Finally, the LSPR nanosensor will be compared to traditional, flat surface, propagating surface plasmon resonance sensors.


Localized surface plasmon resonanceNanosensorSingle nanoparticleSpectroscopyBiosensing

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  1. 1.Department of Chemistry Northwestern UniversityEvanstonUSA