, Volume 372, Issue 2, pp 301-304

Miniature surface-plasmon resonance immunosensors – rapid and repetitive procedure

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Miniaturized immunosensors based on surface-plasmon resonance (SPR) have been developed by using the sensor recently developed by Texas Instruments. By using this sensor for human immunoglobulin G (IgG) rapid and repetitive measurements could be performed by alternate injection of sample and glycine-HCl buffer. A sensor for human serum albumin (HSA) could also be developed similarly. One difficulty in immunosensor development is dissociation of the strongly bound antigen–antibody complex. A "regenerable" immunosensor has also been developed for this reason.

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