Psychopharmacology

, Volume 155, Issue 3, pp 310–314

Reduced serotonin transporter binding in binge eating women

Authors

  • Jyrki T. Kuikka
    • Departments of Clinical Physiology and Neurophysiology, Kuopio University Hospital, 70210 Kuopio, Finland
  • Liisa Tammela
    • Department of Clinical Nutrition, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland
  • Leila Karhunen
    • Department of Clinical Nutrition, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland
  • Aila Rissanen
    • Department of Psychiatry, Helsinki University Central Hospital, 00029 Helsinki, Finland
  • Kim A. Bergström
    • Departments of Clinical Physiology and Neurophysiology, Kuopio University Hospital, 70210 Kuopio, Finland
  • Hannu Naukkarinen
    • Department of Psychiatry, Helsinki University Central Hospital, 00029 Helsinki, Finland
  • Esko Vanninen
    • Departments of Clinical Physiology and Neurophysiology, Kuopio University Hospital, 70210 Kuopio, Finland
  • Jari Karhu
    • Departments of Clinical Physiology and Neurophysiology, Kuopio University Hospital, 70210 Kuopio, Finland
  • Raimo Lappalainen
    • Department of Psychology, University of Tampere, 33014 Tampere, Finland
  • Eila Repo-Tiihonen
    • Department of Forensic Psychiatry, University of Kuopio and Niuvanniemi Hospital, 70240 Kuopio, Finland
  • Jari Tiihonen
    • Department of Forensic Psychiatry, University of Kuopio and Niuvanniemi Hospital, 70240 Kuopio, Finland
  • Matti Uusitupa
    • Department of Clinical Nutrition, University of Kuopio and Kuopio University Hospital, 70210 Kuopio, Finland
Original Investigation

DOI: 10.1007/s002130100716

Cite this article as:
Kuikka, J.T., Tammela, L., Karhunen, L. et al. Psychopharmacology (2001) 155: 310. doi:10.1007/s002130100716

Abstract.

Rationale: There is evidence that abnormalities in brain dopamine, norepinephrine and serotonin metabolism may play an important role in binge eating. Serotonin-active antidepressant drugs have also been found to decrease binge eating. Objective: We investigated serotonin transporter binding in obese binge-eating women. Eleven obese binge-eating and seven obese control women participated in the study. The subjects were not taking any medication known to affect serotonin (5-HT) transporters. Methods: We used single-photon emission tomography (SPECT) with the radioligand 123I-labelled nor-β-CIT, which specifically labels 5-HT transporters. Results: Obese binge-eating women showed significantly decreased 5-HT transporter binding in the mid-brain compared with obese controls (2.1±0.5 versus 2.9±0.5, respectively). Conclusions: SPECT imaging with a ligand specific for 5-HT transporters can be used to assess altered serotonin transporter binding in the living human brain. The results tentatively suggest that 5-HT transporter binding is decreased in binge-eating women.

Binge eating Depression Obesity Serotonin SPECT

Copyright information

© Springer-Verlag 2001