, Volume 142, Issue 2, pp 200–208

Facilitation of sexual behavior in male rats following d-amphetamine-induced behavioral sensitization

  • Dennis F. Fiorino
  • A. G. Phillips

DOI: 10.1007/s002130050880

Cite this article as:
Fiorino, D. & Phillips, A. Psychopharmacology (1999) 142: 200. doi:10.1007/s002130050880


The present study investigated the effect of sensitization, induced by repeated injections of d-amphetamine, on sexual behavior in the naive male rat tested in a drug-free state. Injections of either d-amphetamine (1.5 mg/kg, IP) or saline were given every other day for a total of ten injections, and this regimen induced behavioral sensitization of locomotor activity in drug-treated rats. After a 3-week post-drug period, d-amphetamine-treated rats exhibited facilitated sexual behavior, as indicated by shorter latencies to mount and intromit, and a greater percentage of rats copulating. These rats also exhibited a general increase in the amount of copulation. Furthermore, sensitized rats displayed a facilitated acquisition of sexual behavior (i.e. mount and intromission latency <300 s for 3 consecutive days). After repeated sexual experience, rats pre-treated with d-amphetamine also showed an augmented increase in level changes made in anticipation of the presentation of a receptive female. Finally, enhanced sexual behavior was independent of the environment in which repeated administration of d-amphetamine occurred, indicating that facilitation was not a consequence of conditioned associations between drug and test environment. These results demonstrate that behavioral sensitization due to repeated psychostimulant administration can “cross-sensitize” to a natural motivated behavior, such as sex. Furthermore, the subsequent facilitation of anticipatory sexual behavior (i.e. level changes) after repeated experience in rats previously treated with d-amphetamine suggests that behavioral sensitization can influence incentive learning.

Key words Sensitizationd-AmphetamineSexual behaviorMotivationAppetitiveConsummatoryMesolimbic dopamineConditioning

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Dennis F. Fiorino
    • 1
  • A. G. Phillips
    • 1
  1. 1.University of British Columbia, Department of Psychology, 2136 West Mall, Vancouver BC, Canada V6T 1Z4 e-mail:, Fax: +1-604-822-6923CA