Psychopharmacology

, Volume 141, Issue 1, pp 11–15

Smoking withdrawal, nicotine dependence and prepulse inhibition of the acoustic startle reflex

  • Veena Kumari
  • Jeffrey A. Gray
ORIGINAL INVESTIGATION

DOI: 10.1007/s002130050800

Cite this article as:
Kumari, V. & Gray, J. Psychopharmacology (1999) 141: 11. doi:10.1007/s002130050800

Abstract

The present study examined the relationship between nicotine dependence as measured by the Fagerstrom Tolerance Questionnaire (FTQ) and prepulse inhibition (PPI) of the acoustic startle reflex measured after overnight smoking withdrawal in a non-clinical population of male smokers with no history of psychiatric disorders or drug/alcohol abuse. It was found that smokers who scored high (>median) on the FTQ showed significantly less PPI as compared to those scoring low (<median) on this scale. This finding further supports a role for nicotine in modulation of PPI, as has previously been found in rats and also in human beings.

Key words Prepulse inhibitionAcoustic startle reflexSmoking withdrawalNicotine dependence

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Veena Kumari
    • 1
  • Jeffrey A. Gray
    • 2
  1. 1.Section of Cognitive Psychopharmacology, Department of Psychological Medicine, Institute of Psychiatry, University of London, De Crespigny Park, London SE5 8AF, UKGB
  2. 2.Department of Psychology, Institute of Psychiatry, University of London, De Crespigny Park, London SE5 8AF, UKGB