Psychopharmacology

, Volume 140, Issue 4, pp 421–428

Cyamemazine decreases ethanol intake in rats and convulsions during ethanol withdrawal syndrome in mice

Authors

  • Mickaël Naassila
    • Faculté de Pharmacie, 1 rue des Louvels, F-80000 Amiens, France
  • Elisabeth Legrand
    • UFR de Médecine-Pharmacie de Rouen, BP 97, F-76803 Saint Etienne Rouvray Cédex, France e-mail: daoust@easynet.fr, Fax: +33-3-2282 7672
  • Françoise d’Alche-Birée
    • Rhône Poulenc Rorer Company, 15 rue de la Vanne, F-92120 Montrouge, France
  • M. Daoust
    • Faculté de Pharmacie, 1 rue des Louvels, F-80000 Amiens, France
ORIGINAL INVESTIGATION

DOI: 10.1007/s002130050785

Cite this article as:
Naassila, M., Legrand, E., d’Alche-Birée, F. et al. Psychopharmacology (1998) 140: 421. doi:10.1007/s002130050785

Abstract

The effect of cyamemazine a dopamine D2 receptor antagonist on voluntary ethanol consumption in rats and on ethanol withdrawal in mice was examined. Male Sprague-Dawley rats were tested in a free choice (water and 10% ethanol) experiment and consumed 5 g/kg ethanol daily. Rats were treated daily IP with cyamemazine ( 0.5, 1, or 2 mg/kg) or acamprosate (100 mg/kg) during 2 weeks. Both acamprosate and 1 mg/kg cyamemazine significantly decreased ethanol intake by 45% without affecting either fluid or food intake. The lowest dose of cyamemazine had no effect on alcohol intake but increased food intake. The highest dose had no effect on any variables. During the post-treatment period, only 1 mg/kg cyamemazine decreased both ethanol and fluid intakes. Mice were made dependent on alcohol using a chocolate fluid diet containing increasing concentrations of alcohol and withdrawn after 9 days. Mice were treated with cyamemazine (1 or 0.5 mg/kg, respectively) or with the same doses of lorazepam acutely on the day of withdrawal or chronically (during alcohol treatment). Both chronic and acute cyamemazine and lorazepam treatments decreased convulsions during ethanol withdrawal. Both acute treatments decreased locomotor activity in control and alcohol dependent mice. Chronic treatment had no effect on locomotor activity. We suggest that cyamemazine could reduce alcohol consumption by antagonizing the activation of the dopaminergic pathways during the induction of alcohol dependence. The action of cyamemazine on 5-HT3 receptors could also explain its effect on alcohol convulsions during withdrawal convulsions.

Key words CyamemazineAcamprosateLorazepamAlcohol dependenceAlcohol withdrawalDopamine

Copyright information

© Springer-Verlag Berlin Heidelberg 1998