, Volume 138, Issue 1, pp 9-15

Acute tryptophan depletion attenuates the prolactin response to d-fenfluramine challenge in healthy human subjects

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Prolactin responses to d-fenfluramine (d-FEN) Challenge (0.5 mg/kg PO) were examined after pretreatment with and without acute tryptophan depletion (ATD) in six physically healthy male volunteers. Compared to pretreatment with SHAM-ATD, ATD pretreatment attenuated the PRL response to d-FEN Challenge in all subjects. These data suggest that PRL responses to d-FEN challenge reflect to a substantial degree the activity of newly synthesized 5-HT.

Received: 12 June 1997 /Final version: 19 December 1997