Psychopharmacology

, Volume 133, Issue 4, pp 323–328

IBZM SPECT imaging of striatal dopamine-2 receptors in psychotic patients treated with the novel antipsychotic substance quetiapine in comparison to clozapine and haloperidol

Authors

  • B. Küfferle
    • Department of General Psychiatry, University Hospital for Psychiatry, Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria Fax (+43)1/40-400-3099
  • Johannes Tauscher
    • Department of General Psychiatry, University Hospital for Psychiatry, Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria Fax (+43)1/40-400-3099
  • Susanne Asenbaum
    • Department of General Neurology, University Hospital for Neurology, Vienna, Austria
  • Christine Vesely
    • Department of General Psychiatry, University Hospital for Psychiatry, Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria Fax (+43)1/40-400-3099
  • I. Podreka
    • Department of General Neurology, University Hospital for Neurology, Vienna, Austria
  • Thomas Brücke
    • Department of General Neurology, University Hospital for Neurology, Vienna, Austria
  • Siegfried Kasper
    • Department of General Psychiatry, University Hospital for Psychiatry, Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria Fax (+43)1/40-400-3099
ORIGINAL INVESTIGATION

DOI: 10.1007/s002130050409

Cite this article as:
Küfferle, B., Tauscher, J., Asenbaum, S. et al. Psychopharmacology (1997) 133: 323. doi:10.1007/s002130050409

Abstract

We investigated the striatal dopamine-2 (D2) receptor occupancy caused by different antipsychotic substances in 18 psychotic patients (16 with schizophrenic and two with schizoaffective disorder according to DSM-IV) with single photon emission computed tomography (SPECT) using 123I-iodobenzamide (IBZM) as tracer substance. Four patients were treated with the novel antipsychotic compound quetiapine (300–700 mg/day), six with clozapine (300–600 mg/ day) and eight with haloperidol (10–20 mg/day). They were compared with eight healthy controls. Measurement of S/F ratios and consecutive calculation of D2 receptor occupancy revealed a significantly lower striatal D2 occupancy rate with quetiapine and clozapine in comparison to haloperidol. In correspondence with the low striatal D2 receptor occupancy rates and again in contrast to the haloperidol treatment group, there were no extrapyramidal motor side-effects (EPS) in the quetiapine and clozapine treatment groups. Therefore, the reported data support the position that quetiapine can be considered to be an atypical antipsychotic substance due to its relatively weak striatal D2 receptor blocking property and therefore its low propensity to induce EPS.

Key words NeurolepticsAtypical antipsychoticsDopamine-2 receptorsQuetiapineIBZMSPECTSchizophrenia

Copyright information

© Springer-Verlag Berlin Heidelberg 1997