Psychopharmacology

, Volume 133, Issue 1, pp 99–101

Frontal 5-HT2A receptors studied in depressive patients during chronic treatment by selective serotonin reuptake inhibitors

  • J. M. Massou
  • C. Trichard
  • D. Attar-Levy
  • A. Feline
  • E. Corruble
  • B. Beaufils
  • J. L. Martinot
RAPID COMMUNICATION

DOI: 10.1007/s002130050377

Cite this article as:
Massou, J., Trichard, C., Attar-Levy, D. et al. Psychopharmacology (1997) 133: 99. doi:10.1007/s002130050377

Abstract

To investigate adaptative changes of 5-HT2A receptors induced by SSRIs, six patients chronically treated for a depressive episode (four with fluoxetine, two with fluvoxamine) were studied with PET and [18F]setoperone. They were compared to eight untreated depressive patients. The mean frontal to cerebellum radioactivity concentration ratio, an index of the [18F]setoperone specific binding to 5-HT2A receptors, was higher in treated than in untreated patients, when age was taken into account. This suggests that chronic treatment by SSRIs could induce an up-regulation of the 5-HT2A receptors, and that 5-HT2A receptor down-regulation is not a common mechanism for the therapeutic effects of all serotoninergic antidepressive drugs.

Key words Serotonin selective reuptake inhibitors 5-HT2A receptor Positron emission tomography Depression 

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • J. M. Massou
    • 1
  • C. Trichard
    • 1
  • D. Attar-Levy
    • 3
  • A. Feline
    • 4
  • E. Corruble
    • 5
  • B. Beaufils
    • 2
  • J. L. Martinot
    • 1
  1. 1.INSERM U 334, CEA, Service Hospitalier Frédéric Joliot, 4 place du général Leclerc, F-91406 Orsay, FranceFR
  2. 2.Service de Psychiatrie, Hôpital Corentin-Celton, 37 Boulevard Gambetta, F-92130 Issy Les Moulineaux, FranceFR
  3. 3.Service Hospitalo-universitaire de Psychiatrie, Hôpital Ste Anne, 1 rue Cabanis, F-75014 Paris, FranceFR
  4. 4.Service de psychiatrie, hôpital Bicêtre, 78 rue du général Leclerc, F-94270 Le Kremlin-Bicêtre, FranceFR
  5. 5.Service de psychiatrie, Hôpital Paul Brousse, avenue P.V. Couturier, F-94804 Villejuif, FranceFR