Psychopharmacology

, Volume 132, Issue 2, pp 107–124

Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

Authors

  • J. N. Crawley
    • Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Building 10, Room 4D11, Bethesda, MD 20892-1375, USA
  • John K. Belknap
    • Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health Sciences University and VA Medical Center, Portland, OR 97201, USA
  • Allan Collins
    • Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80303, USA
  • John C. Crabbe
    • Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health Sciences University and VA Medical Center, Portland, OR 97201, USA
  • Wayne Frankel
    • The Jackson Laboratory, Bar Harbor, ME 04609, USA
  • Norman Henderson
    • Department of Psychology, Oberlin College, Oberlin, OH 44074-1086, USA
  • Robert J. Hitzemann
    • Department of Psychiatry, State University of New York, Stony Brook, NY 11794–8101, USA
  • Stephen C. Maxson
    • Biobehavioral Sciences Graduate Degree Program and Department of Psychology, University of Connecticut, Storrs, CT 06269-4154, USA
  • Lucinda L. Miner
    • Molecular Neurobiology Laboratory, National Institute on Drug Abuse, Baltimore, MD 21224, USA
  • Alcino J. Silva
    • Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
  • Jeanne M. Wehner
    • Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80303, USA
  • Anthony Wynshaw-Boris
    • Laboratory of Genetic Disease Research, National Institute, Human Genome Research Institute, Bethesda, MD 20892-4470, USA
  • R. Paylor
    • Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Building 10, Room 4D11, Bethesda, MD 20892-1375, USA
REVIEW

DOI: 10.1007/s002130050327

Cite this article as:
Crawley, J., Belknap, J., Collins, A. et al. Psychopharmacology (1997) 132: 107. doi:10.1007/s002130050327

Abstract

 Choosing the best genetic strains of mice for developing a new knockout or transgenic mouse requires extensive knowledge of the endogenous traits of inbred strains. Background genes from the parental strains may interact with the mutated gene, in a manner which could severely compromise the interpretation of the mutant phenotype. The present overview summarizes the literature on a wide variety of behavioral traits for the 129, C57BL/6, DBA/2, and many other inbred strains of mice. Strain distributions are described for open field activity, learning and memory tasks, aggression, sexual and parental behaviors, acoustic startle and prepulse inhibition, and the behavioral actions of ethanol, nicotine, cocaine, opiates, antipsychotics, and anxiolytics. Using the referenced information, molecular geneticists can choose optimal parental strains of mice, and perhaps develop new embryonic stem cell progenitors, for new knockouts and transgenics to investigate gene function, and to serve as animal models in the development of novel therapeutics for human genetic diseases.

Key words MouseInbred strainsBehaviorGeneticsLocomotionOpen field activityLearningMemoryAggressionParental behaviorsAcoustic startlePrepulse inhibitionAlcoholNicotineCocaineOpiatesHaloperidolDiazepamBreedingEmbryonic stem cell linesTransgenicKnockoutsNull mutation
Download to read the full article text

Copyright information

© Springer-Verlag Berlin Heidelberg 1997