Psychopharmacology

, Volume 131, Issue 3, pp 264–270

CP-94,253: a selective serotonin1B (5-HT1B) agonist that promotes satiety

  • Michelle D. Lee
  • K. J. Simansky
ORIGINAL INVESTIGATION

DOI: 10.1007/s002130050292

Cite this article as:
Lee, M. & Simansky, K. Psychopharmacology (1997) 131: 264. doi:10.1007/s002130050292

Abstract

The selective 5-HT1B agonist CP-94,253 (3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxypyrrolo[3,2-b] pyridine) (5–40 μmol/kg) reduced the intake of both pellets and a 10% solution of sucrose (ID50 = 12.5 and 22.8 μmol/kg, respectively) in mildly deprived rats. Time-sampled observations revealed that CP-94,253 terminated feeding earlier, without disrupting the continuity of feeding. CP-94,253 increased standing but did not promote resting during satiation. Microstructural analysis of licking indicated that CP-94,253 decreased the frequency, but not the size, of bursts and clusters of licks without altering oral motor efficiency. The peripherally acting 5-HT1B agonist, CP-93,129 (3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one) had no effect on food intake. These results imply that CP-94,253 probes a role for central 5-HT1B receptors in the regulation of meal size and duration, but that recruitment of other 5-HT receptor subtypes may be needed for the full expression of satiety.

Key words CP-94 253 CP-93 129 Serotonin 5-HT1B receptors Feeding Satiety Microstructure of ingestion Meal size 

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Michelle D. Lee
    • 1
  • K. J. Simansky
    • 1
  1. 1.Department of Pharmacology, MCP, ? Hahnemann School of Medicine, Allegheny University of the Health Sciences, 3200 Henry Avenue, Philadelphia, PA 19129, USAUS

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