Psychopharmacology

, Volume 130, Issue 2, pp 152–158

In vivo effects on striatal dopamine D2 receptor binding by the novel atypical antipsychotic drug sertindole – a 123I IBZM single photon emission tomography (SPET) study

  • L. S. Pilowsky
  • P. O’Connell
  • N. Davies
  • G. F. Busatto
  • D. C. Costa
  • R. M. Murray
  • P. J. Ell
  • R. W. Kerwin
ORIGINAL INVESTIGATION

DOI: 10.1007/s002130050223

Cite this article as:
Pilowsky, L., O’Connell, P., Davies, N. et al. Psychopharmacology (1997) 130: 152. doi:10.1007/s002130050223

Abstract

The novel antipsychotic drug sertindole has an atypical pharmacological profile. We have estimated striatal D2 dopamine binding in schizophrenic patients treated with sertindole using 123I iodobenzamide (IBZM) SPET. Patients were recruited from a clinical trial of sertindole’s tolerability and efficacy. Striatal D2 binding in sertindole-treated patients (n = 5), was compared with previously reported data from clozapine (n = 10); olanzapine (n = 6); typical antipsychotic responsive (n = 10); and risperidone (n = 6)-treated groups. Mean PANSS (structured clinical interview for the positive and negative syndrome scale) scores showed clinical improvement in the sertindole group. Few extrapyramidal side effects (EPS) were recorded [average Simpson-Angus (SAS) score = 2.6]. Sertindole-treated patients had mean D2 binding indices (± SE) significantly lower than clozapine-treated patients (1.19 ± 0.04) versus (1.49 ± 0.04), and olanzapine-treated patients (1.41 ± 0.06); and similar to those of risperidone (1.24 ± 0.04) and typical antipsychotic responsive (1.25 ± 0.05) treated patients. In this patient sample the preliminary evidence suggests that sertindole’s decreased tendency to induce EPS at clinically therapeutic doses is not due to limited occupancy of striatal D2 receptors in vivo, and as is the case for risperidone, patients are protected from EPS by some other intrinsic effect of the drug.

Key words Sertindole Clozapine Atypical antipsychotic drugs Single photon emission tomography 

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • L. S. Pilowsky
    • 1
  • P. O’Connell
    • 1
  • N. Davies
    • 1
  • G. F. Busatto
    • 1
  • D. C. Costa
    • 2
  • R. M. Murray
    • 1
  • P. J. Ell
    • 2
  • R. W. Kerwin
    • 1
  1. 1.Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK GB
  2. 2.Institute of Nuclear Medicine, UCMSM, Mortimer Street, London W1N 8AA, UKGB