Psychopharmacology

, Volume 129, Issue 3, pp 285–288

The ability of THA treatment to increase cortical alpha waves is related to apolipoprotein E genotype of Alzheimer disease patients

  • Paavo Riekkinen
  • Hilkka Soininen
  • Juhani Partanen
  • Ari Pääkkönen
  • Seppo Helisalmi
  • Paavo Riekkinen
Original Investigation

DOI: 10.1007/s002130050192

Cite this article as:
Riekkinen, P., Soininen, H., Partanen, J. et al. Psychopharmacology (1997) 129: 285. doi:10.1007/s002130050192

Abstract

In a previous study, we reported that Alzheimer disease (AD) patients with an apolipoprotein E (APOE) ɛ4 allele (+ APOE4) show more severe loss of nucleus basalis (NB) cholinergic cells than patients without ɛ4 alleles (− APOE4). The present study investigates the effects of a single oral administration of THA 25 or 50 mg on cortical spectral EEG activity in + (five APOE4/4, six APOE4/3) and − APOE4 (eight APOE3/3) AD patients. THA 25 mg had no significant effect on EEG activity in any AD patients. However, THA 50 mg increased alpha activity and alpha/theta ratio in − APOE4 patients. In contrast, THA 50 mg had no effect on EEG activity in + APOE4 patients. This result tentatively suggests that in AD patients APOE genotype may affect the response of cortical electrical arousal to cholinergic therapy that enhances the efficacy of presynaptic NB axons.

Key words

THAEEG slowingApolipoprotein EAlzheimer disease

Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Paavo Riekkinen
    • 1
  • Hilkka Soininen
    • 1
  • Juhani Partanen
    • 2
  • Ari Pääkkönen
    • 2
  • Seppo Helisalmi
    • 3
  • Paavo Riekkinen
    • 4
  1. 1.Department of NeurologyUniversity Hospital of KuopioKuopioFinland
  2. 2.Department of Clinical NeurophysiologyUniversity Hospital of KuopioKuopioFinland
  3. 3.Unit of Clinical Genetics of the Department of Gynecology and ObstetricsUniversity Hospital of KuopioKuopioFinland
  4. 4.A.I.Virtanen Institute, Department of NeuroscienceUniversity of KuopioKuopioFinland